Antipsychotics and antidepressants

Michael mbughuni, Caren J. Blacker, Jesse Seegmiller, Hemamalini Ketha, Amy B. Karger

Research output: Chapter in Book/Report/Conference proceedingChapter


Antidepressants and antipsychotics are neuropsychiatric medications used to treat depressive disorders and psychosis, respectively. This chapter covers the toxicological aspects of several typical and atypical antipsychotics and antidepressants, including selective serotonin reuptake inhibitors, selective norepinephrine-serotonin reuptake inhibitors (SNRIs), tricyclic antidepressants, and monoamine oxidase inhibitors. Prevalence and epidemiology of toxic exposures of these drug classes are also presented. Compounds in these classes that are most commonly associated with overdose or toxicity are discussed in detail. A guide for the management of patients presenting with antidepressant or antipsychotic overdose is provided. Finally, analytical methods for clinical laboratory assessment are discussed.

Original languageEnglish (US)
Title of host publicationToxicology Cases for the Clinical and Forensic Laboratory
Number of pages10
ISBN (Electronic)9780128158463
ISBN (Print)9780128163733
StatePublished - Jan 1 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc. All rights reserved.


  • Antipsychotics
  • MAOIs
  • SNRIs
  • SSRIs
  • TCAs
  • antidepressants


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