Antiplatelet therapy

Aspirin resistance and all that jazz!

Afshin A Divani, Nicole D Zantek, Afshin Borhani-Haghighi, Gundu H.R. Rao

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Platelets play a crucial role in the pathogenesis of atherosclerosis, thrombosis, and stroke. Aspirin used alone or in combination with other antiplatelet drugs has been shown to offer significant benefit to patients at high risk of vascular events. Resistance to the action of aspirin may decrease this benefit. Aspirin resistance has been defined by clinical and/or laboratory criteria; however, detection by laboratory methods prior to experiencing a clinical event will likely provide the greatest opportunity for intervention. Numerous laboratory methods with different cutoff points have been used to evaluate the resistance. Noncompliance with aspirin treatment has also confounded studies. A single assay is currently insufficient to establish resistance. Combinations of results to confirm compliance and platelet inhibition may identify "at-risk" individuals who truly have aspirin resistance. The most effective strategy for managing patients with aspirin resistance is unknown; however, studies are currently underway to address this issue.

Original languageEnglish (US)
Pages (from-to)5-18
Number of pages14
JournalClinical and Applied Thrombosis/Hemostasis
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Aspirin
Therapeutics
Blood Platelets
Platelet Aggregation Inhibitors
Compliance
Blood Vessels
Atherosclerosis
Thrombosis
Stroke

Keywords

  • acetylsalicylic acid
  • antiplatelet therapy
  • arachidonic acid
  • aspirin resistance
  • cyclooxygenase
  • prostacycline
  • stroke
  • thromboxane
  • vascular disease

Cite this

Antiplatelet therapy : Aspirin resistance and all that jazz! / Divani, Afshin A; Zantek, Nicole D; Borhani-Haghighi, Afshin; Rao, Gundu H.R.

In: Clinical and Applied Thrombosis/Hemostasis, Vol. 19, No. 1, 01.01.2013, p. 5-18.

Research output: Contribution to journalReview article

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