Antioxidant and anti-inflammatory effects of exercise: Role of redox signaling

L. L. Ji, Y. Zhang

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Contraction-induced production of reactive oxygen species (ROS) has been implicated in oxidative stress to skeletal muscle for the past few decades. As research advances more evidence has revealed a more complete role of ROS under both physiological and pathological conditions. The current review postulated that moderate intensity of physical exercise has antioxidant and anti-inflammatory effects due to the operation and cross-talks of several redox-sensitive signal transduction pathways. The functional roles and mechanisms of action of the nuclear factor κB, mitogen-activated protein kinase, and peroxisome proliferator-activated receptor γ co-activator 1α are highlighted.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalFree Radical Research
Issue number1
StatePublished - Jan 2014

Bibliographical note

Funding Information:
The authors wish to thank the Wisconsin Alumni Research Foundation (WARF), University of Minnesota Twin Cities, the Natural Science Foundation of China, and Tianjin Municipal Sci-tech-innovation Base Project for financial support.

Copyright 2014 Elsevier B.V., All rights reserved.


  • Antioxidant
  • Exercise
  • MAPK
  • NFκB
  • Reactive oxygen species
  • Signaling


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