Abstract
Contraction-induced production of reactive oxygen species (ROS) has been implicated in oxidative stress to skeletal muscle for the past few decades. As research advances more evidence has revealed a more complete role of ROS under both physiological and pathological conditions. The current review postulated that moderate intensity of physical exercise has antioxidant and anti-inflammatory effects due to the operation and cross-talks of several redox-sensitive signal transduction pathways. The functional roles and mechanisms of action of the nuclear factor κB, mitogen-activated protein kinase, and peroxisome proliferator-activated receptor γ co-activator 1α are highlighted.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3-11 |
| Number of pages | 9 |
| Journal | Free Radical Research |
| Volume | 48 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2014 |
Bibliographical note
Funding Information:The authors wish to thank the Wisconsin Alumni Research Foundation (WARF), University of Minnesota Twin Cities, the Natural Science Foundation of China, and Tianjin Municipal Sci-tech-innovation Base Project for financial support.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
Keywords
- Antioxidant
- Exercise
- MAPK
- NFκB
- Reactive oxygen species
- Signaling