Antinociception induced by 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), an N-methyl-d-aspartate (NMDA) competitive antagonist, plus 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist, differs from that induced by MK-801 plus DNQX

Virginia M. Goett, Alice A. Larson

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Excitatory amino acid receptors have been implicated in mediating pain. 3-((±)-2-Carboxypiperazin4-yl)-propyl-1-phosphonic acid (CPP), a competitive N-methyl-d-aspartate (NMDA) antagonist and MK-801, a phencyclidine (PCP) ligand and non-competitive NMDA antagonist, were injected intrathecally in mice alone or in combination with 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist. When tested in the formalin model of pain, antinociception following CPP plus DNQX was greater than that after MK-801 plus DNQX in both the acute and tonic phases. These dissimilarities are not consistent with activity of CPP and MK-801 at the same sites in the spinal cord.

Original languageEnglish (US)
Pages (from-to)334-338
Number of pages5
JournalBrain Research
Volume642
Issue number1-2
DOIs
StatePublished - Apr 11 1994

Keywords

  • 3-((±)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
  • 6,7-Dinitroquinoxaline-2,3-dione
  • Formalin
  • MK-801
  • N-Methyl-d-aspartate
  • Non-N-methyl-d-aspartate
  • PCP
  • Pain

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