Antineutrophil cytoplasmic autoantibody-positive crescentic glomerulonephritis as a complication of treatment with propylthiouracil in children

Beth A. Vogt, Youngki Kim, J. Charles Jennette, Ronald J. Falk, Barbara A. Burke, Alan Sinaiko

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

Propylthiouracil, which is commonly used in the treatment of hyperthyroidism, has been associated in adults with antineutrophil cytoplasmic autoantibody, a serologic marker of vasculitis. Severe renal disease has not been reported as a complication of therapy with this drug. We report severe antineutrophil cytoplasmic autoantibody-positive vasculitis in children receiving propylthiouracil, as well as rapidly progressive crescentic glomerulonephritis after administration of this drug.

Original languageEnglish (US)
Pages (from-to)986-988
Number of pages3
JournalThe Journal of pediatrics
Volume124
Issue number6
DOIs
StatePublished - Jun 1994

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