Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

George R. Pettit; John C. Knight; Delbert L. Herald; Robin K. Pettit; Fiona Hogan; Venugopal J.R.V. Mukku; John S. Hamblin; Michael J. Dodson; Jean Charles Chapuis

doi:10.1021/np800603u

Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

George R. Pettit
, John C. Knight
, Delbert L. Herald
, Robin K. Pettit
, Fiona Hogan
, Venugopal J.R.V. Mukku
, John S. Hamblin
, Michael J. Dodson
, Jean Charles Chapuis

Math, Science, and Technology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI ₅₀'s of 10 ^-4-10 ^-5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.

Original language	English (US)
Pages (from-to)	366-371
Number of pages	6
Journal	Journal of Natural Products
Volume	72
Issue number	3
DOIs	https://doi.org/10.1021/np800603u
State	Published - Mar 27 2009

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SDG 3 Good Health and Well-being

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title = "Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris",

abstract = "Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10 -4-10 -5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.",

author = "Pettit, \{George R.\} and Knight, \{John C.\} and Herald, \{Delbert L.\} and Pettit, \{Robin K.\} and Fiona Hogan and Mukku, \{Venugopal J.R.V.\} and Hamblin, \{John S.\} and Dodson, \{Michael J.\} and Chapuis, \{Jean Charles\}",

year = "2009",

month = mar,

day = "27",

doi = "10.1021/np800603u",

language = "English (US)",

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T1 - Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

AU - Pettit, George R.

AU - Knight, John C.

AU - Herald, Delbert L.

AU - Pettit, Robin K.

AU - Hogan, Fiona

AU - Mukku, Venugopal J.R.V.

AU - Hamblin, John S.

AU - Dodson, Michael J.

AU - Chapuis, Jean Charles

PY - 2009/3/27

Y1 - 2009/3/27

N2 - Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10 -4-10 -5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.

AB - Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10 -4-10 -5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.

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AN - SCOPUS:65249103936

SN - 0163-3864

VL - 72

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 3

ER -

Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

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