Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

George R. Pettit; John C. Knight; Delbert L. Herald; Robin K. Pettit; Fiona Hogan; Venugopal J.R.V. Mukku; John S. Hamblin; Michael J. Dodson; Jean Charles Chapuis

doi:10.1021/np800603u

Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

George R. Pettit, John C. Knight, Delbert L. Herald, Robin K. Pettit, Fiona Hogan, Venugopal J.R.V. Mukku, John S. Hamblin, Michael J. Dodson, Jean Charles Chapuis

Math, Science, and Technology

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Abstract

Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI ₅₀'s of 10 ^-4-10 ^-5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.

Original language	English (US)
Pages (from-to)	366-371
Number of pages	6
Journal	Journal of Natural Products
Volume	72
Issue number	3
DOIs	https://doi.org/10.1021/np800603u
State	Published - Mar 27 2009

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abstract = "Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10 -4-10 -5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.",

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AU - Pettit, George R.

AU - Knight, John C.

AU - Herald, Delbert L.

AU - Pettit, Robin K.

AU - Hogan, Fiona

AU - Mukku, Venugopal J.R.V.

AU - Hamblin, John S.

AU - Dodson, Michael J.

AU - Chapuis, Jean Charles

PY - 2009/3/27

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Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

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