Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents

George R. Pettit; Venugopal J.R.V. Mukku; Gordon Cragg; Delbert L. Herald; John C. Knight; Cherry L. Herald; Jean Charles Chapuis

doi:10.1021/np068050q

Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents

George R. Pettit, Venugopal J.R.V. Mukku, Gordon Cragg, Delbert L. Herald, John C. Knight, Cherry L. Herald, Jean Charles Chapuis

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high-resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.

Original language	English (US)
Pages (from-to)	130-133
Number of pages	4
Journal	Journal of Natural Products
Volume	71
Issue number	1
DOIs	https://doi.org/10.1021/np068050q
State	Published - Jan 2008
Externally published	Yes

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AU - Herald, Delbert L.

AU - Knight, John C.

AU - Herald, Cherry L.

AU - Chapuis, Jean Charles

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Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents

Abstract

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