Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents

George R. Pettit, Venugopal J.R.V. Mukku, Gordon Cragg, Delbert L. Herald, John C. Knight, Cherry L. Herald, Jean Charles Chapuis

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high-resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)130-133
Number of pages4
JournalJournal of Natural Products
Volume71
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

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    Pettit, G. R., Mukku, V. J. R. V., Cragg, G., Herald, D. L., Knight, J. C., Herald, C. L., & Chapuis, J. C. (2008). Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents. Journal of Natural Products, 71(1), 130-133. https://doi.org/10.1021/np068050q