Antimineralization treatments for bioprosthetic heart valves: Assessment of efficacy and safety

F. J. Schoen, R. J. Levy, S. L. Hilbert, R. W. Bianco

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Since calcification limits the durability of contemporary bioprosthetic heart valves, antimineralization treatments are being widely investigated. Potential antimineralization treatments must have sustained prevention of mineralization without adverse effects. The preclinical investigation of efficacy and safety of antimineralization treatments comprises four essential steps: (1) subcutaneous implantation in small animals, (2) in vitro biomechanical studies of hemodynamics and durability, (3) morphology of unimplanted valves, and (4) circulatory implants in large animals.

Original languageEnglish (US)
Pages (from-to)1285-1288
Number of pages4
JournalJournal of Thoracic and Cardiovascular Surgery
Volume104
Issue number5
DOIs
StatePublished - 1992

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