Antimicrobial use quantification in adult dairy cows – Part 1 – Standardized regimens as a method for describing antimicrobial use

Nora  Schrag; Michael D. Apley; Sandra M Godden; Brian  Lubbers; Randall Singer

doi:10.1111/zph.12766

Antimicrobial use quantification in adult dairy cows – Part 1 – Standardized regimens as a method for describing antimicrobial use

Nora Schrag, Michael D. Apley, Sandra M Godden, Brian Lubbers, Randall Singer

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15 Scopus citations

Abstract

This study describes a process to acquire and convert farm treatment records into a standardized regimen format. Multiple sources of on-farm data were utilized to convert the original treatment records to standardized regimens, enabling the generation of objective, granular descriptions of antimicrobial use. These standard regimen descriptions allow antimicrobial use data to be qualitatively stratified by active substance, disease syndrome treated, use category, and route of administration. Quantitative distributions are available for the grams of active substance per administration, the grams of active substance per regimen, the number of administrations, number of days of therapy and the time frame between the first and last administration. Granular quantification by this method informs future research, surveillance and policy.

Original language	English (US)
Pages (from-to)	51-68
Number of pages	18
Journal	Zoonoses and Public Health
Volume	67 Suppl 1
Issue number	S1
DOIs	https://doi.org/10.1111/zph.12766
State	Published - Nov 17 2020

Bibliographical note

Funding Information:
Thank you to the producers who volunteered their time, data and expertise in helping to identify useful antimicrobial use measures. Collaboration on data management and analysis were provided by the Center for Epidemiology and Animal Health (CEAH) at USDA:APHIS:VS in Fort Collins, Colorado. Funding for this project was made possible, in part, by the US Food and Drug Administration through grant number U01FD005868. Views expressed do not necessarily reflect the official policies of the Department of Health and Human Services; nor does any mention of trade names, commercial practices, or organization imply endorsement by the United States Government. Special thanks to Dr. Kathe Bjork (USDA‐APHIS CEAH) and Dr. Susan Bright and Dr. Anna Nevius (FDA) for collaborations on data management and review of the manuscript.

Publisher Copyright:
© 2020 Wiley-VCH GmbH

Keywords

antibacterial agents
days of therapy
defined daily dose
drug utilization
pharmacoepidemiology
resistance

PubMed: MeSH publication types

Journal Article
Research Support, U.S. Gov't, P.H.S.

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abstract = "This study describes a process to acquire and convert farm treatment records into a standardized regimen format. Multiple sources of on-farm data were utilized to convert the original treatment records to standardized regimens, enabling the generation of objective, granular descriptions of antimicrobial use. These standard regimen descriptions allow antimicrobial use data to be qualitatively stratified by active substance, disease syndrome treated, use category, and route of administration. Quantitative distributions are available for the grams of active substance per administration, the grams of active substance per regimen, the number of administrations, number of days of therapy and the time frame between the first and last administration. Granular quantification by this method informs future research, surveillance and policy.",

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Antimicrobial use quantification in adult dairy cows – Part 1 – Standardized regimens as a method for describing antimicrobial use

Abstract

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Keywords

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