Antimicrobial resistance distribution differs among methicillin resistant Staphylococcus aureus sequence type (ST) 5 isolates from health care and agricultural sources

Samantha J. Hau, Jisun S. Haan, Peter R. Davies, Timothy Frana, Tracy L. Nicholson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Antimicrobial resistance (AMR) is an expanding public health concern and methicillin resistant Staphylococcus aureus (MRSA) is a notable example. Since the discovery of livestock associated MRSA (LA-MRSA), public health concerns have arisen surrounding the potential of LA-MRSA isolates to serve as a reservoir for AMR determinants. In this study, we compare swine associated LA-MRSA ST5 and human clinical MRSA ST5 isolates for phenotypic antimicrobial susceptibilities determined via broth microdilution and genotypic determinants of AMR using whole genome sequencing and comparative genomic analysis to identify AMR elements. Swine associated LA-MRSA ST5 isolates exhibited phenotypic resistance to fewer antibiotics than clinical MRSA ST5 isolates from humans with no swine contact. Distinct genomic AMR elements were harbored by each subgroup, with little overlap in shared AMR genes between swine associated LA-MRSA ST5 and clinical MRSA ST5 isolates. Our results demonstrate that phenotypic antimicrobial susceptibilities and genotypic determinants of AMR among swine associated LA-MRSA ST5 and clinical MRSA ST5 isolates are separate and distinct.

Original languageEnglish (US)
Article number2102
JournalFrontiers in Microbiology
Volume9
Issue numberSEP
DOIs
StatePublished - Sep 11 2018

Keywords

  • Agriculture
  • Antimicrobial resistance
  • LA-MRSA
  • Mobile genetic elements
  • Staphylococcus aureus
  • Swine

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