Antimicrobial properties and dentin bonding strength of magnesium phosphate cements

G. Mestres, M. Abdolhosseini, Walter R Bowles, S. H. Huang, Conrado Aparicio, Sven-Ulrik Gorr, M. P. Ginebra

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The main objective of this work was to assess the antimicrobial properties and the dentin-bonding strength of novel magnesium phosphate cements (MPC). Three formulations of MPC, consisting of magnesium oxide and a phosphate salt, NH4H2PO4, NaH2PO4 or a mixture of both, were evaluated. As a result of the setting reaction, MPC transformed into either struvite (MgNH4PO4·6H 2O) when NH4H2PO4 was used or an amorphous magnesium sodium phosphate when NaH2PO4 was used. The MPC had appropriate setting times for hard tissue applications, high early compressive strengths and higher strength of bonding to dentin than commercial mineral trioxide aggregate cement. Bacteriological studies were performed with fresh and aged cements against three bacterial strains, Escherichia coli, Pseudomonas aeruginosa (planktonic and in biofilm) and Aggregatibacter actinomycetemcomitans. These bacteria have been associated with infected implants, as well as other frequent hard tissue related infections. Extracts of different compositions of MPC had bactericidal or bacteriostatic properties against the three bacterial strains tested. This was associated mainly with a synergistic effect between the high osmolarity and alkaline pH of the MPC. These intrinsic antimicrobial properties make MPC preferential candidates for applications in dentistry, such as root fillers, pulp capping agents and cavity liners.

Original languageEnglish (US)
Pages (from-to)8384-8393
Number of pages10
JournalActa Biomaterialia
Issue number9
StatePublished - Sep 2013

Bibliographical note

Funding Information:
This work was supported by the Spanish Ministry of Science and Innovation through Project MAT2009-13547 and through a FPU short-stay scholarship to GM. Support for MPG was also received though the “ICREA Academia” award for excellence in research, funded by the Generalitat de Catalunya . Antimicrobial assays were supported by research funds from the University of Minnesota School of Dentistry . The authors are sincerely grateful to S. Triviño and M. Marques for their help with preliminary antimicrobial studies.


  • Antibacterial properties
  • Bonding strength
  • Dental cement
  • Magnesium phosphate cement
  • Struvite


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