Antimicrobial efficacy of external fixator pins coated with a lipid stabilized hydroxyapatite/chlorhexidine complex to prevent pin tract infection in a goat model

E. Schuyler DeJong, Thomas M. DeBerardino, Daniel E. Brooks, Bradley J. Nelson, Allison A. Campbell, Craig R. Bottoni, Anthony E. Pusateri, Ronald S. Walton, Charles H. Guymon, Albert T. McManus

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

Background: Pin tract infection is a common complication of external fixation. An antiinfective external fixator pin might help to reduce the incidence of pin tract infection and improve pin fixation. Methods: Stainless steel and titanium external fixator pins, with and without a lipid stabilized hydroxyapatite/chlorhexidine coating, were evaluated in a goat model. Two pins contaminated with an identifiable Staphylococcus aureus strain were inserted into each tibia of 12 goats. The pin sites were examined dally. On day 14, the animals were killed, and the pin tips cultured. Insertion and extraction torques were measured. Results: Infection developed in 100% of uncoated pins, whereas coated pins demonstrated 4.2% infected, 12.5% colonized, and the remainder, 83.3%, had no growth (p < 0.01). Pin coating decreased the percent loss of fixation torque over uncoated pins (p = 0.04). Conclusion: These results demonstrate that the lipid stabilized hydroxyapatite/chlorhexidine coating was successful in decreasing infection and improving fixation of external fixator pins.

Original languageEnglish (US)
Pages (from-to)1008-1014
Number of pages7
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume50
Issue number6
DOIs
StatePublished - 2001

Keywords

  • Chlorhexidine
  • External fixation
  • Hydroxyapatite
  • Infection
  • Pin

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