Antimicrobial agent resistance in Neisseria gonorrhoeae in St. Paul, Minnesota

Richard T. Lally, Bert F. Woolfrey, Mary E. Gresser-Burn, Keith Henry

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In a prospective survey of 283 Neisseria gonorrhoeae isolated in St. Paul, Minnesota, 5% were found to produce β-lactamase, and 11% were resistant to penicillin by chromosomal mediation, thus indicating a hyperendemic level of resistance according to Centers for Disease Control guidelines. A significant level of chromosomal resistance (30%) was noted for tetracycline, and MICs for spectinomycin approached the upper limits of susceptibility for a large number of isolates. The need for uniformity in agar dilution test methodology is discussed, and the variability in antimicrobial agent interpretive breakpoint criteria is illustrated by comparing penicillin breakpoints published by the Centers for Disease Control with those of the National Committee for Clinical Laboratory Standards as applied to the study isolates.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalDiagnostic Microbiology and Infectious Disease
Issue number1
StatePublished - May 1988

Bibliographical note

Funding Information:
This research was supported by grant 8-440 from the St. Paul Ramsey Research Foundation. We wish to thank the Microbiology Laboratory at St. Panl-Ramsey Medical Center and Room 111 at the St. Paul Division of Public Health for their valuable technical assistance.


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