Antimicrobial activity of the semisynthetic compound, hexahydrocolupulone

T. E. Stephan, E. O. Ngo, Patricia Ferrieri, J. M. Besser, L. M. Nutter

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In this study we demonstrate that hexahydrocolupulone (HHC) more effectively inhibits the growth in vitro of Gram-positive organisms than Mycobacterium tuberculosis or Escherichia coli. Vancomycin-resistant Enterococcus faecium, methicillin-resistant Staphylococcus aureus, and coagulase-negative staphylococci were inhibited by HHC at concentrations ≤ 4.06 mg/L. Growth inhibition profiles varied according to the microorganism evaluated (static for S. aureus and bactericidal for Bacillus subtilis).

Original languageEnglish (US)
Pages (from-to)519-522
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Issue number4
StatePublished - Oct 1998


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