Antimicrobial activity of the semisynthetic compound, hexahydrocolupulone

T. E. Stephan; E. O. Ngo; Patricia Ferrieri; J. M. Besser; L. M. Nutter

doi:10.1093/jac/42.4.519

Antimicrobial activity of the semisynthetic compound, hexahydrocolupulone

T. E. Stephan, E. O. Ngo, Patricia Ferrieri, J. M. Besser, L. M. Nutter

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

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Abstract

In this study we demonstrate that hexahydrocolupulone (HHC) more effectively inhibits the growth in vitro of Gram-positive organisms than Mycobacterium tuberculosis or Escherichia coli. Vancomycin-resistant Enterococcus faecium, methicillin-resistant Staphylococcus aureus, and coagulase-negative staphylococci were inhibited by HHC at concentrations ≤ 4.06 mg/L. Growth inhibition profiles varied according to the microorganism evaluated (static for S. aureus and bactericidal for Bacillus subtilis).

Original language	English (US)
Pages (from-to)	519-522
Number of pages	4
Journal	Journal of Antimicrobial Chemotherapy
Volume	42
Issue number	4
DOIs	https://doi.org/10.1093/jac/42.4.519
State	Published - Oct 1998

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AU - Besser, J. M.

AU - Nutter, L. M.

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AB - In this study we demonstrate that hexahydrocolupulone (HHC) more effectively inhibits the growth in vitro of Gram-positive organisms than Mycobacterium tuberculosis or Escherichia coli. Vancomycin-resistant Enterococcus faecium, methicillin-resistant Staphylococcus aureus, and coagulase-negative staphylococci were inhibited by HHC at concentrations ≤ 4.06 mg/L. Growth inhibition profiles varied according to the microorganism evaluated (static for S. aureus and bactericidal for Bacillus subtilis).

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Antimicrobial activity of the semisynthetic compound, hexahydrocolupulone

Abstract

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