Antimalarial, antiviral, and antitoxoplasmosis norsesterterpene peroxide acids from the red sea sponge Diacarnus erythraeanus

Khalid A. El Sayed, Mark T. Hamann, Nadia E. Hashish, W. Thomas Shier, Michelle Kelly, Anis A. Khan

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

A new norsesterterpene acid, named muqubilone (1), along with the known sigmosceptrellin-B and muqubilin were isolated from the Red Sea sponge Diacarnus erythraeanus. The structure determination of 1 was based primarily on 1D and 2D NMR analyses. Sigmosceptrellin-B exhibits significant in vitro antimalarial activity against Plasmodium falciparum (D6 and W2 clones) with IC50 values of 1200 and 3400 ng/mL, respectively. Muqubilin and 1 show in vitro antiviral activity against herpes simplex type 1 (HSV-1) with ED50 values of 7.5 and 30 μg/mL, respectively. Muqubilin and sigmosceptrellin-B display potent in vitro activity against Toxoplasma gondii at a concentration of 0.1 μM without significant toxicity.

Original languageEnglish (US)
Pages (from-to)522-524
Number of pages3
JournalJournal of Natural Products
Volume64
Issue number4
DOIs
StatePublished - Apr 2001

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