Antimüllerian hormone among women with and without type 1 diabetes: the Epidemiology of Diabetes Interventions and Complications Study and the Michigan Bone Health and Metabolism Study

Catherine Kim, Carrie Karvonen-Gutierrez, Shengchun Kong, Valerie Arends, Michael W Steffes, Daniel S. McConnell, John F. Randolph, Siobán D. Harlow

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective To compare concentrations of antimüllerian hormone (AMH) in women with and without type 1 diabetes. Design Cross-sectional analysis of longitudinal studies, adjusting for repeated measures. Setting Not applicable. Patient(s) Women aged 30–45 years who had not undergone oophorectomy, hysterectomy, or natural menopause at the time of AMH measurement were included (n = 376 in the Michigan Bone Health and Metabolism Study and n = 321 in the Epidemiology of Interventions and Complications Study). Linear mixed regression was used to evaluate whether AMH concentrations differed by diabetes status, adjusting for repeated measurements of AMH within individual women, body mass index, smoking status, and oral contraceptive use. Intervention(s) None. Main Outcome Measure(s) Concentrations of AMH. Result(s) In unadjusted comparisons, women with and without diabetes had similar median AMH values before 35 years of age, although women with type 1 diabetes had a lower proportion of women with elevated AMH concentrations (≥5.0 ng/dL). After adjustment for covariates and multiple observations per woman, log AMH concentrations were significantly lower among women with type 1 diabetes compared with women without diabetes (β-coefficient −1.27, 95% confidence interval [−2.18, −0.36] in fully adjusted models) before 35 years of age. Conclusion(s) Before 35 years of age, women with type 1 diabetes have lower AMH levels than women without diabetes. Further investigation is needed to determine the etiologies of this difference and how it may contribute to reproductive disorders among women with type 1 diabetes.

Original languageEnglish (US)
Pages (from-to)1446-1452
Number of pages7
JournalFertility and Sterility
Volume106
Issue number6
DOIs
StatePublished - Nov 1 2016

Fingerprint

Diabetes Complications
Type 1 Diabetes Mellitus
Epidemiology
Hormones
Bone and Bones
Health
Ovariectomy
Oral Contraceptives
Menopause
Hysterectomy
Longitudinal Studies
Linear Models
Body Mass Index
Cross-Sectional Studies
Smoking
Outcome Assessment (Health Care)
Confidence Intervals

Keywords

  • Ovarian hormones
  • reproductive endocrinology
  • type 1 diabetes
  • women's health

Cite this

Antimüllerian hormone among women with and without type 1 diabetes : the Epidemiology of Diabetes Interventions and Complications Study and the Michigan Bone Health and Metabolism Study. / Kim, Catherine; Karvonen-Gutierrez, Carrie; Kong, Shengchun; Arends, Valerie; Steffes, Michael W; McConnell, Daniel S.; Randolph, John F.; Harlow, Siobán D.

In: Fertility and Sterility, Vol. 106, No. 6, 01.11.2016, p. 1446-1452.

Research output: Contribution to journalArticle

Kim, Catherine ; Karvonen-Gutierrez, Carrie ; Kong, Shengchun ; Arends, Valerie ; Steffes, Michael W ; McConnell, Daniel S. ; Randolph, John F. ; Harlow, Siobán D. / Antimüllerian hormone among women with and without type 1 diabetes : the Epidemiology of Diabetes Interventions and Complications Study and the Michigan Bone Health and Metabolism Study. In: Fertility and Sterility. 2016 ; Vol. 106, No. 6. pp. 1446-1452.
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abstract = "Objective To compare concentrations of antim{\"u}llerian hormone (AMH) in women with and without type 1 diabetes. Design Cross-sectional analysis of longitudinal studies, adjusting for repeated measures. Setting Not applicable. Patient(s) Women aged 30–45 years who had not undergone oophorectomy, hysterectomy, or natural menopause at the time of AMH measurement were included (n = 376 in the Michigan Bone Health and Metabolism Study and n = 321 in the Epidemiology of Interventions and Complications Study). Linear mixed regression was used to evaluate whether AMH concentrations differed by diabetes status, adjusting for repeated measurements of AMH within individual women, body mass index, smoking status, and oral contraceptive use. Intervention(s) None. Main Outcome Measure(s) Concentrations of AMH. Result(s) In unadjusted comparisons, women with and without diabetes had similar median AMH values before 35 years of age, although women with type 1 diabetes had a lower proportion of women with elevated AMH concentrations (≥5.0 ng/dL). After adjustment for covariates and multiple observations per woman, log AMH concentrations were significantly lower among women with type 1 diabetes compared with women without diabetes (β-coefficient −1.27, 95{\%} confidence interval [−2.18, −0.36] in fully adjusted models) before 35 years of age. Conclusion(s) Before 35 years of age, women with type 1 diabetes have lower AMH levels than women without diabetes. Further investigation is needed to determine the etiologies of this difference and how it may contribute to reproductive disorders among women with type 1 diabetes.",
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AU - Kong, Shengchun

AU - Arends, Valerie

AU - Steffes, Michael W

AU - McConnell, Daniel S.

AU - Randolph, John F.

AU - Harlow, Siobán D.

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AB - Objective To compare concentrations of antimüllerian hormone (AMH) in women with and without type 1 diabetes. Design Cross-sectional analysis of longitudinal studies, adjusting for repeated measures. Setting Not applicable. Patient(s) Women aged 30–45 years who had not undergone oophorectomy, hysterectomy, or natural menopause at the time of AMH measurement were included (n = 376 in the Michigan Bone Health and Metabolism Study and n = 321 in the Epidemiology of Interventions and Complications Study). Linear mixed regression was used to evaluate whether AMH concentrations differed by diabetes status, adjusting for repeated measurements of AMH within individual women, body mass index, smoking status, and oral contraceptive use. Intervention(s) None. Main Outcome Measure(s) Concentrations of AMH. Result(s) In unadjusted comparisons, women with and without diabetes had similar median AMH values before 35 years of age, although women with type 1 diabetes had a lower proportion of women with elevated AMH concentrations (≥5.0 ng/dL). After adjustment for covariates and multiple observations per woman, log AMH concentrations were significantly lower among women with type 1 diabetes compared with women without diabetes (β-coefficient −1.27, 95% confidence interval [−2.18, −0.36] in fully adjusted models) before 35 years of age. Conclusion(s) Before 35 years of age, women with type 1 diabetes have lower AMH levels than women without diabetes. Further investigation is needed to determine the etiologies of this difference and how it may contribute to reproductive disorders among women with type 1 diabetes.

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