Antileishmanial potential of thiourea-based derivatives: design, synthesis and biological activity

Keyphrases

• Biological Activity 100%
• Thiourea 100%
• Design Activity 100%
• L. Major 100%
• Derivative Design 100%
• Antileishmanial Potential 100%
• Methylenetetrahydrofolate Reductase (MTHFR) 50%
• Synthesized Compounds 50%
• Pteridine Reductase 1 50%
• High Activity 25%
• Cytotoxicity 25%
• Safety Profile 25%
• In Vivo Efficacy 25%
• Leishmaniasis 25%
• Therapeutic Potential 25%
• Normal Human 25%
• Antifolate 25%
• HEK293 25%
• IC50 Value 25%
• Enzyme Inhibition 25%
• Inhibitory Potential 25%
• Folic Acid 25%
• Protozoan Parasites 25%
• Thiourea Derivatives 25%
• Active Pocket 25%
• Human Embryonic Kidney Cells 25%
• Neglected Tropical Diseases 25%
• Target Enzyme 25%
• Docking Experiments 25%
• Promastigote 25%
• Leishmania Donovani 25%
• Amastigote 25%
• Antileishmanial Activity 25%
• Sand Fly Vectors 25%
• Antileishmanial Effects 25%
• Leishmania Tropica 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Biological Activity 100%
• Thiourea 100%
• Oxidoreductase 100%
• Dihydrofolate Reductase 100%
• Pteridine 100%
• Normal Human 50%
• Protozoon 50%
• Enzyme Inhibition 50%
• Phlebotominae 50%
• Folic Acid Antagonist 50%
• Folic Acid 50%
• Thiourea Derivative 50%
• IC50 50%
• Leishmaniasis 50%
• Amastigote 50%
• Promastigote 50%
• Cytotoxicity 50%
• Tropical Disease 50%
• Diseases 50%