Antihypertensive treatment of acute cerebral hemorrhage (ATACH): Rationale and design

Adnan I. Qureshi

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

This trial is a multicenter open-labeled pilot trial to determine the tolerability and safety of three escalating levels of antihypertensive treatment goals for acute hypertension in 60 subjects with supratentorial intracerebral hemorrhage (ICH). The pilot trial is the natural development of numerous case series evaluating the effect of antihypertensive treatment of acute hypertension in subjects with ICH. The proposed trial will have important public health implications by providing necessary information for a definitive phase III study regarding the efficacy of antihypertensive treatment of acute hypertension in subjects with ICH. The specific aims of the present pilot study are to: (1) Determine the tolerability of the treatment as assessed by achieving and maintaining three different systolic blood pressure goals with intravenous nicardipine infusion for 18 to 24 hours postictus in subjects with ICH who present within 6 hours of symptom onset; (2) Define the safety, assessed by the rate of neurological deterioration during treatment and serious adverse events, of three escalating systolic blood pressure treatment goals using intravenous nicardipine infusion; and (3) Obtain preliminary estimates of the treatment effect using the rate of hematoma expansion (within 24 hours) and modified Rankin scale and Barthel index at 3 months following symptom onset.

Original languageEnglish (US)
Pages (from-to)56-66
Number of pages11
JournalNeurocritical Care
Volume6
Issue number1
DOIs
StatePublished - Feb 2007

Bibliographical note

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Fingerprint

Dive into the research topics of 'Antihypertensive treatment of acute cerebral hemorrhage (ATACH): Rationale and design'. Together they form a unique fingerprint.

Cite this