Antihypertensive drug therapy with captopril in children and adolescents

Alan R. Sinaiko, Clifford E. Kashtan, Bernard L. Mirkin

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Captopril was administered to three groups of hypertensive children and adolescents: 1) patients with renal disease; 2) neonates with umbilical artery related hypertension; and 3) post-renal transplant patients. In older children with renal disease, increasing the captopril dose above 0.5 mg/kg did not improve the antihypertensive response. A maximal drug concentrations occurred one hour after dosing, and captopril concentration returned to predose levels by eight hours. Neonates responded to significantly lower doses of captopril (0.01-0.5 mg/kg) and the duration of response to higher doses appeared to be longer than that observed in older children. In post-renal transplant patients, blood pressure decreased after captopril in 94% of subjects, but in 62% a concomitant increase in serum creatinine was observed (correlation [r]=0.55, p<02). This increase could not be correlated with renal biopsy histopathology. Thus, captopril has proven to be an effective antihypertensive agent in children over a broad age range and for a variety of clinical conditons.

Original languageEnglish (US)
Pages (from-to)829-839
Number of pages11
JournalClinical and Experimental Hypertension
Issue number4-5
StatePublished - 1986


  • Blood pressure
  • Captopril
  • Drug disposition
  • Newborn
  • Renal disease
  • Renal transplant


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