Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011

Xian Qi, Lunbiao Cui, Yongjun Jiao, Yuning Pan, Xihan Li, Rongqiang Zu, Xiang Huo, Bin Wu, Fengyang Tang, Yongchun Song, Minghao Zhou, Hua Wang, Carol J. Cardona, Zheng Xing

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Cross-species transmission of influenza A viruses from swine to human occurs occasionally. In 2011, an influenza A H1N1 virus, A/Jiangsu/ALS1/2011 (JS/ALS1/2011), was isolated from a boy who suffered from severe pneumonia in China. The virus is closely related antigenically and genetically to avian-like swine H1N1 viruses that have recently been circulating in pigs in China and that were initially detected in European pig populations in 1979. The isolation of JS/ALS1/2011 provides additional evidence that swine influenza viruses can occasionally infect humans and emphasizes the importance of reinforcing influenza virus surveillance in both pigs and humans.

Original languageEnglish (US)
Pages (from-to)39-53
Number of pages15
JournalArchives of Virology
Volume158
Issue number1
DOIs
StatePublished - Jan 2013

Bibliographical note

Funding Information:
The study was supported by the Natural Science Foundation of Jiangsu Province (BK2009434 and BK2009431), the Innovation Platform for Public Health Emergency Preparedness and Response (NO.ZX201109), the Jiangsu Province Key Medical Talent Foundation (RC2011084 and RC2011191), and the “333” Projects of Jiangsu Province. We are grateful to Prof. Xuejie Yu from the Department of Pathology, University of Texas Medical Branch for reviewing the manuscript.

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