Antigen-specific culture of memory-like CD8 T cells for adoptive immunotherapy

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Abstract

Cytotoxic T cells typically are expanded ex vivo in culture with IL2 for adoptive immunotherapy. This culture period leads to a differentiated phenotype and acquisition of effector function, as well as a loss of in vivo proliferative capability and antitumor efficacy. Here, we report antigen-specific and polyclonal expansion of cytotoxic T cells in a cocktail of cytokines and small molecules that leads to a memory-like phenotype in mouse and human cells even during extended culture, leading to enhanced in vivo expansion and tumor control in mice.

Original languageEnglish (US)
Pages (from-to)839-845
Number of pages7
JournalCancer Immunology Research
Volume2
Issue number9
DOIs
StatePublished - Sep 1 2014

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