Antigen presentation to naive CD4 T cells in the lymph node

Andrea A. Itano, Marc K. Jenkins

Research output: Contribution to journalReview articlepeer-review

347 Scopus citations

Abstract

Although the presentation of peptide - major histocompatibility complex class II (pMHC class II) complexes to CD4 T cells has been studied extensively in vitro, knowledge of this process in vivo is limited. Unlike the in vitro situation, antigen presentation in vivo takes place within a complex microenvironment in which the movements of antigens, antigen-presenting cells (APCs) and T cells are governed by anatomic constraints. Here we review developments in the areas of lymph node architecture, APC subsets and T cell activation that have shed light on how antigen presentation occurs in the lymph nodes.

Original languageEnglish (US)
Pages (from-to)733-739
Number of pages7
JournalNature immunology
Volume4
Issue number8
DOIs
StatePublished - Aug 2003

Fingerprint Dive into the research topics of 'Antigen presentation to naive CD4 T cells in the lymph node'. Together they form a unique fingerprint.

Cite this