Antigen presentation to naive CD4 T cells in the lymph node

Andrea A. Itano, Marc K. Jenkins

Research output: Contribution to journalReview articlepeer-review

367 Scopus citations


Although the presentation of peptide - major histocompatibility complex class II (pMHC class II) complexes to CD4 T cells has been studied extensively in vitro, knowledge of this process in vivo is limited. Unlike the in vitro situation, antigen presentation in vivo takes place within a complex microenvironment in which the movements of antigens, antigen-presenting cells (APCs) and T cells are governed by anatomic constraints. Here we review developments in the areas of lymph node architecture, APC subsets and T cell activation that have shed light on how antigen presentation occurs in the lymph nodes.

Original languageEnglish (US)
Pages (from-to)733-739
Number of pages7
JournalNature immunology
Issue number8
StatePublished - Aug 2003

Bibliographical note

Funding Information:
We thank T. Leonard for help with the animation. Supported by grants from the National Institutes of Health and the Irvington Institute of Immunological Research.


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