Antigen presentation by Langerhans cells

Botond Z. Igyártó, Daniel H. Kaplan

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


Langerhans cells and other skin-resident dendritic cells (DC) are required for the development of cutaneous adaptive immune responses. In vivo experiments using mice with selective DC-subset deficiencies and ex vivo experiments using isolated DC suggests that each subset makes a unique contribution to the adaptive response. This review focuses on the functional outcome of antigen presentation by Langerhans cells. Special attention is given to their ability to promote CD4 T cell differentiation in a variety of inflammatory contexts and whether this subset has the capacity to cross-prime CD8 T cells.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalCurrent Opinion in Immunology
Issue number1
StatePublished - Feb 2013

Bibliographical note

Funding Information:
This work was supported by a grant from the NIH AR056632 and AR060794 and the American Skin Association . BZI was supported by a grant from the Dermatology Foundation .


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