Antigen-induced experimental septic arthritis in rabbits after intraarticular injection of staphylococcus aureus

Maren L. Mahowald, Lance Peterson, John Raskind, Donald A. Raddatz, Rex Shafer, Dale Gerding, Donald A. Raddatz

Research output: Contribution to journalArticle

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Abstract

With the Dumonde-Glynn model of antigen-induced arthritis, a rabbit model was developed to examine the histopathologic differences between normal and arthritic joints in the same animal infected by intraarticular injections of Staphylococcus aureus. Microscopic examination of whole joint sections and a quantitative histopathologic scale were used to compare changes in all the articular components of 17 normal and 17 arthritic joints infected for less than two weeks. The histological changes were more severe in infected arthritic joints than in infected normal joints (mean ± SD total histology score, 13.8 ± 2.4 and 9.3 ± 4.0, respectively; P <.001). In infected arthritic joints, subsynovial abscesses extended into subchondral bone via the pannus of chronic synovitis at articular margins and intraarticular attachments of cruciate ligaments, rather than by initial cartilage destruction and direct extension into subchondral bone.

Original languageEnglish (US)
Pages (from-to)273-282
Number of pages10
JournalJournal of Infectious Diseases
Volume154
Issue number2
DOIs
StatePublished - Aug 1986

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    Mahowald, M. L., Peterson, L., Raskind, J., Raddatz, D. A., Shafer, R., Gerding, D., & Raddatz, D. A. (1986). Antigen-induced experimental septic arthritis in rabbits after intraarticular injection of staphylococcus aureus. Journal of Infectious Diseases, 154(2), 273-282. https://doi.org/10.1093/infdis/154.2.273