Antifungal and antiviral products of marine organisms

Randy Chi Fai Cheung, Jack Ho Wong, Wen Liang Pan, Yau Sang Chan, Cui Ming Yin, Xiu Li Dan, He Xiang Wang, Evandro Fei Fang, Sze Kwan Lam, Patrick Hung Kui Ngai, Li Xin Xia, Fang Liu, Xiu Yun Ye, Guo Qing Zhang, Qing Hong Liu, Ou Sha, Peng Lin, Chan Ki, Adnan A. Bekhit, Alaa El Din BekhitDavid Chi Cheong Wan, Xiu Juan Ye, Jiang Xia, Tzi Bun Ng

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates produce a variety of products with antifungal activity including bacterial chitinases, lipopeptides, and lactones; fungal (-)-sclerotiorin and peptaibols, purpurides B and C, berkedrimane B and purpuride; algal gambieric acids A and B, phlorotannins; 3,5-dibromo-2-(3,5- dibromo-2-methoxyphenoxy)phenol, spongistatin 1, eurysterols A and B, nortetillapyrone, bromotyrosine alkaloids, bis-indole alkaloid, ageloxime B and (-)-ageloxime D, haliscosamine, hamigeran G, hippolachnin A from sponges; echinoderm triterpene glycosides and alkene sulfates; molluscan kahalalide F and a 1485-Da peptide with a sequence SRSELIVHQR; and cepalochordate chitotriosidase and a 5026.9-Da antifungal peptide. The antiviral compounds from marine organisms include bacterial polysaccharide and furan-2-yl acetate; fungal macrolide, purpurester A, purpurquinone B, isoindolone derivatives, alterporriol Q, tetrahydroaltersolanol C and asperterrestide A, algal diterpenes, xylogalactofucan, alginic acid, glycolipid sulfoquinovosyldiacylglycerol, sulfated polysaccharide p-KG03, meroditerpenoids, methyl ester derivative of vatomaric acid, lectins, polysaccharides, tannins, cnidarian zoanthoxanthin alkaloids, norditerpenoid and capilloquinol; crustacean antilipopolysaccharide factors, molluscan hemocyanin; echinoderm triterpenoid glycosides; tunicate didemnin B, tamandarins A and B and; tilapia hepcidin 1-5 (TH 1-5), seabream SauMx1, SauMx2, and SauMx3, and orange-spotted grouper β-defensin. Although the mechanisms of antifungal and antiviral activities of only some of the aforementioned compounds have been elucidated, the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated. It is also worthwhile to test the marine antimicrobials for possible synergism with existing drugs. The prospects of employing them in clinical practice are promising in view of the wealth of these compounds from marine organisms. The compounds may also be used in agriculture and the food industry.

Original languageEnglish (US)
Pages (from-to)3475-3494
Number of pages20
JournalApplied Microbiology and Biotechnology
Issue number8
StatePublished - Apr 2014
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgments We gratefully acknowledge the award of an RFCID research grant (no. 10090812) from Food and Health Bureau, The Government of Hong Kong Special Administrative Region, and grants from National Natural Science Foundation of China (nos. 81201270 and 81273275).


  • Antifungal
  • Antiviral
  • Marine organisms
  • Products


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