TY - JOUR
T1 - Antifungal and antiviral products of marine organisms
AU - Cheung, Randy Chi Fai
AU - Wong, Jack Ho
AU - Pan, Wen Liang
AU - Chan, Yau Sang
AU - Yin, Cui Ming
AU - Dan, Xiu Li
AU - Wang, He Xiang
AU - Fang, Evandro Fei
AU - Lam, Sze Kwan
AU - Ngai, Patrick Hung Kui
AU - Xia, Li Xin
AU - Liu, Fang
AU - Ye, Xiu Yun
AU - Zhang, Guo Qing
AU - Liu, Qing Hong
AU - Sha, Ou
AU - Lin, Peng
AU - Ki, Chan
AU - Bekhit, Adnan A.
AU - Bekhit, Alaa El Din
AU - Wan, David Chi Cheong
AU - Ye, Xiu Juan
AU - Xia, Jiang
AU - Ng, Tzi Bun
N1 - Funding Information:
Acknowledgments We gratefully acknowledge the award of an RFCID research grant (no. 10090812) from Food and Health Bureau, The Government of Hong Kong Special Administrative Region, and grants from National Natural Science Foundation of China (nos. 81201270 and 81273275).
PY - 2014/4
Y1 - 2014/4
N2 - Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates produce a variety of products with antifungal activity including bacterial chitinases, lipopeptides, and lactones; fungal (-)-sclerotiorin and peptaibols, purpurides B and C, berkedrimane B and purpuride; algal gambieric acids A and B, phlorotannins; 3,5-dibromo-2-(3,5- dibromo-2-methoxyphenoxy)phenol, spongistatin 1, eurysterols A and B, nortetillapyrone, bromotyrosine alkaloids, bis-indole alkaloid, ageloxime B and (-)-ageloxime D, haliscosamine, hamigeran G, hippolachnin A from sponges; echinoderm triterpene glycosides and alkene sulfates; molluscan kahalalide F and a 1485-Da peptide with a sequence SRSELIVHQR; and cepalochordate chitotriosidase and a 5026.9-Da antifungal peptide. The antiviral compounds from marine organisms include bacterial polysaccharide and furan-2-yl acetate; fungal macrolide, purpurester A, purpurquinone B, isoindolone derivatives, alterporriol Q, tetrahydroaltersolanol C and asperterrestide A, algal diterpenes, xylogalactofucan, alginic acid, glycolipid sulfoquinovosyldiacylglycerol, sulfated polysaccharide p-KG03, meroditerpenoids, methyl ester derivative of vatomaric acid, lectins, polysaccharides, tannins, cnidarian zoanthoxanthin alkaloids, norditerpenoid and capilloquinol; crustacean antilipopolysaccharide factors, molluscan hemocyanin; echinoderm triterpenoid glycosides; tunicate didemnin B, tamandarins A and B and; tilapia hepcidin 1-5 (TH 1-5), seabream SauMx1, SauMx2, and SauMx3, and orange-spotted grouper β-defensin. Although the mechanisms of antifungal and antiviral activities of only some of the aforementioned compounds have been elucidated, the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated. It is also worthwhile to test the marine antimicrobials for possible synergism with existing drugs. The prospects of employing them in clinical practice are promising in view of the wealth of these compounds from marine organisms. The compounds may also be used in agriculture and the food industry.
AB - Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates produce a variety of products with antifungal activity including bacterial chitinases, lipopeptides, and lactones; fungal (-)-sclerotiorin and peptaibols, purpurides B and C, berkedrimane B and purpuride; algal gambieric acids A and B, phlorotannins; 3,5-dibromo-2-(3,5- dibromo-2-methoxyphenoxy)phenol, spongistatin 1, eurysterols A and B, nortetillapyrone, bromotyrosine alkaloids, bis-indole alkaloid, ageloxime B and (-)-ageloxime D, haliscosamine, hamigeran G, hippolachnin A from sponges; echinoderm triterpene glycosides and alkene sulfates; molluscan kahalalide F and a 1485-Da peptide with a sequence SRSELIVHQR; and cepalochordate chitotriosidase and a 5026.9-Da antifungal peptide. The antiviral compounds from marine organisms include bacterial polysaccharide and furan-2-yl acetate; fungal macrolide, purpurester A, purpurquinone B, isoindolone derivatives, alterporriol Q, tetrahydroaltersolanol C and asperterrestide A, algal diterpenes, xylogalactofucan, alginic acid, glycolipid sulfoquinovosyldiacylglycerol, sulfated polysaccharide p-KG03, meroditerpenoids, methyl ester derivative of vatomaric acid, lectins, polysaccharides, tannins, cnidarian zoanthoxanthin alkaloids, norditerpenoid and capilloquinol; crustacean antilipopolysaccharide factors, molluscan hemocyanin; echinoderm triterpenoid glycosides; tunicate didemnin B, tamandarins A and B and; tilapia hepcidin 1-5 (TH 1-5), seabream SauMx1, SauMx2, and SauMx3, and orange-spotted grouper β-defensin. Although the mechanisms of antifungal and antiviral activities of only some of the aforementioned compounds have been elucidated, the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated. It is also worthwhile to test the marine antimicrobials for possible synergism with existing drugs. The prospects of employing them in clinical practice are promising in view of the wealth of these compounds from marine organisms. The compounds may also be used in agriculture and the food industry.
KW - Antifungal
KW - Antiviral
KW - Marine organisms
KW - Products
UR - http://www.scopus.com/inward/record.url?scp=84898911263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898911263&partnerID=8YFLogxK
U2 - 10.1007/s00253-014-5575-0
DO - 10.1007/s00253-014-5575-0
M3 - Review article
C2 - 24562325
AN - SCOPUS:84898911263
SN - 0175-7598
VL - 98
SP - 3475
EP - 3494
JO - Applied Microbiology and Biotechnology
JF - Applied Microbiology and Biotechnology
IS - 8
ER -
