Antifungal activity of plumericin and isoplumericin

Dharmendra Singh, Umakant Sharma, Parveen Kumar, Yogesh K. Gupta, M. P. Dobhal, Sarman Singh

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

This study evaluated the in vitro antifungal activity of the chloroform extract of Plumeria bicolor and its phytoconstituents plumericin and isoplumericin against Candida species and Cryptococcus neoformans by measuring the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). Plumericin's consistently high activity against Candida albicans, C. krusei, C. glabrata, C. tropicalis and Cryptococcus neoformans was more potent than isoplumericin and the standard antifungal drug nystatin suggesting its potential as a drug candidate for candidiasis and cryptococcosis.

Original languageEnglish (US)
Pages (from-to)1567-1568
Number of pages2
JournalNatural Product Communications
Volume6
Issue number11
StatePublished - Dec 5 2011

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Keywords

  • Candidiasis
  • Cryptococcosis
  • Isoplumericin
  • Plumeria bicolor
  • Plumericin

Cite this

Singh, D., Sharma, U., Kumar, P., Gupta, Y. K., Dobhal, M. P., & Singh, S. (2011). Antifungal activity of plumericin and isoplumericin. Natural Product Communications, 6(11), 1567-1568.