Antifungal activity of plumericin and isoplumericin

Dharmendra Singh; Umakant Sharma; Parveen Kumar; Yogesh K. Gupta; M. P. Dobhal; Sarman Singh

doi:10.1177/1934578x1100601101

Antifungal activity of plumericin and isoplumericin

Dharmendra Singh, Umakant Sharma, Parveen Kumar, Yogesh K. Gupta, M. P. Dobhal, Sarman Singh

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

This study evaluated the in vitro antifungal activity of the chloroform extract of Plumeria bicolor and its phytoconstituents plumericin and isoplumericin against Candida species and Cryptococcus neoformans by measuring the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). Plumericin's consistently high activity against Candida albicans, C. krusei, C. glabrata, C. tropicalis and Cryptococcus neoformans was more potent than isoplumericin and the standard antifungal drug nystatin suggesting its potential as a drug candidate for candidiasis and cryptococcosis.

Original language	English (US)
Pages (from-to)	1567-1568
Number of pages	2
Journal	Natural Product Communications
Volume	6
Issue number	11
DOIs	https://doi.org/10.1177/1934578x1100601101
State	Published - Nov 2011
Externally published	Yes

Keywords

Candidiasis
Cryptococcosis
Isoplumericin
Plumeria bicolor
Plumericin

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10.1177/1934578x1100601101

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title = "Antifungal activity of plumericin and isoplumericin",

abstract = "This study evaluated the in vitro antifungal activity of the chloroform extract of Plumeria bicolor and its phytoconstituents plumericin and isoplumericin against Candida species and Cryptococcus neoformans by measuring the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). Plumericin's consistently high activity against Candida albicans, C. krusei, C. glabrata, C. tropicalis and Cryptococcus neoformans was more potent than isoplumericin and the standard antifungal drug nystatin suggesting its potential as a drug candidate for candidiasis and cryptococcosis.",

keywords = "Candidiasis, Cryptococcosis, Isoplumericin, Plumeria bicolor, Plumericin",

author = "Dharmendra Singh and Umakant Sharma and Parveen Kumar and Gupta, {Yogesh K.} and Dobhal, {M. P.} and Sarman Singh",

year = "2011",

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doi = "10.1177/1934578x1100601101",

language = "English (US)",

volume = "6",

pages = "1567--1568",

journal = "Natural Product Communications",

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AU - Singh, Dharmendra

AU - Sharma, Umakant

AU - Kumar, Parveen

AU - Gupta, Yogesh K.

AU - Dobhal, M. P.

AU - Singh, Sarman

PY - 2011/11

Y1 - 2011/11

N2 - This study evaluated the in vitro antifungal activity of the chloroform extract of Plumeria bicolor and its phytoconstituents plumericin and isoplumericin against Candida species and Cryptococcus neoformans by measuring the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). Plumericin's consistently high activity against Candida albicans, C. krusei, C. glabrata, C. tropicalis and Cryptococcus neoformans was more potent than isoplumericin and the standard antifungal drug nystatin suggesting its potential as a drug candidate for candidiasis and cryptococcosis.

AB - This study evaluated the in vitro antifungal activity of the chloroform extract of Plumeria bicolor and its phytoconstituents plumericin and isoplumericin against Candida species and Cryptococcus neoformans by measuring the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). Plumericin's consistently high activity against Candida albicans, C. krusei, C. glabrata, C. tropicalis and Cryptococcus neoformans was more potent than isoplumericin and the standard antifungal drug nystatin suggesting its potential as a drug candidate for candidiasis and cryptococcosis.

KW - Candidiasis

KW - Cryptococcosis

KW - Isoplumericin

KW - Plumeria bicolor

KW - Plumericin

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ER -

Antifungal activity of plumericin and isoplumericin

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