Antifungal activity from 14-helical β-peptides

Amy J. Karlsson, William C. Pomerantz, Bernard Weisblum, Samuel H. Gellman, Sean P. Palecek

Research output: Contribution to journalArticlepeer-review

125 Scopus citations

Abstract

We have discovered that short β-peptides (9 or 10 residues) designed to adopt globally amphiphilic helical conformations display significant antifungal activity. The most promising β-peptides cause little lysis of human red blood cells at concentrations that kill Candida albicans, a common human fungal pathogen. Since fungi are eukaryotes, discrimination between fungal and human cells is a significant finding. Our β-peptides are active under assay conditions that mimic physiological ionic strength; in contrast, α-helix-forming host-defense α-peptides are inactive against C. albicans under these conditions.

Original languageEnglish (US)
Pages (from-to)12630-12631
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number39
DOIs
StatePublished - Oct 4 2006

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