Antifouling for Electrochemically Biosensing in Body Fluids

Wenzheng He; Changdong Zhou; Yang Lin; Yuxin Tian; Liying Liu; Qifu Zhang; Xiongying Ye; Tianhong Cui

doi:10.1109/MEMS49605.2023.10052511

Antifouling for Electrochemically Biosensing in Body Fluids

Wenzheng He, Changdong Zhou, Yang Lin, Yuxin Tian, Liying Liu, Qifu Zhang, Xiongying Ye, Tianhong Cui

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

This paper presents a simple and robust antifouling sensor based on a nano-wrinkle electrode with bovine serum albumin for electrochemically detecting small molecules in complex body fluids. The nano-wrinkle was prepared by a one-step shrinking technique, being capable of excluding large proteins in physical structures and enhancing the response of small molecules. The prepared sensor demonstrates excellent antifouling capability under discontinuous or continuous exposure to proteins or fetal calf serum, which preserves 97% of its original signal after a 21-day exposure to fetal calf serum and enabled the quantification of dopamine in the protein-coexisted environment with a low limit of detection (LOD) (1.09 μM) and a wide detection range from 20 to 1105 μM.

Original language	English (US)
Title of host publication	2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	285-288
Number of pages	4
ISBN (Electronic)	9781665493086
DOIs	https://doi.org/10.1109/MEMS49605.2023.10052511
State	Published - 2023
Event	36th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2023 - Munich, Germany Duration: Jan 15 2023 → Jan 19 2023

Publication series

Name	2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS)

Conference

Conference	36th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2023
Country/Territory	Germany
City	Munich
Period	1/15/23 → 1/19/23

Bibliographical note

Publisher Copyright:
© 2023 IEEE.

Keywords

Antifouling
Dopamine
Electrochemical sensor
Nano-wrinkle
Serum
Shrinking technique

Publisher link

10.1109/MEMS49605.2023.10052511

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He, W., Zhou, C., Lin, Y., Tian, Y., Liu, L., Zhang, Q., Ye, X., & Cui, T. (2023). Antifouling for Electrochemically Biosensing in Body Fluids. In 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023 (pp. 285-288). (2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS)). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMS49605.2023.10052511

Antifouling for Electrochemically Biosensing in Body Fluids. / He, Wenzheng; Zhou, Changdong; Lin, Yang et al.
2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023. Institute of Electrical and Electronics Engineers Inc., 2023. p. 285-288 (2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

He, W, Zhou, C, Lin, Y, Tian, Y, Liu, L, Zhang, Q, Ye, X & Cui, T 2023, Antifouling for Electrochemically Biosensing in Body Fluids. in 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023. 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS), Institute of Electrical and Electronics Engineers Inc., pp. 285-288, 36th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2023, Munich, Germany, 1/15/23. https://doi.org/10.1109/MEMS49605.2023.10052511

He W, Zhou C, Lin Y, Tian Y, Liu L, Zhang Q et al. Antifouling for Electrochemically Biosensing in Body Fluids. In 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023. Institute of Electrical and Electronics Engineers Inc. 2023. p. 285-288. (2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMS49605.2023.10052511

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abstract = "This paper presents a simple and robust antifouling sensor based on a nano-wrinkle electrode with bovine serum albumin for electrochemically detecting small molecules in complex body fluids. The nano-wrinkle was prepared by a one-step shrinking technique, being capable of excluding large proteins in physical structures and enhancing the response of small molecules. The prepared sensor demonstrates excellent antifouling capability under discontinuous or continuous exposure to proteins or fetal calf serum, which preserves 97% of its original signal after a 21-day exposure to fetal calf serum and enabled the quantification of dopamine in the protein-coexisted environment with a low limit of detection (LOD) (1.09 μM) and a wide detection range from 20 to 1105 μM.",

keywords = "Antifouling, Dopamine, Electrochemical sensor, Nano-wrinkle, Serum, Shrinking technique",

author = "Wenzheng He and Changdong Zhou and Yang Lin and Yuxin Tian and Liying Liu and Qifu Zhang and Xiongying Ye and Tianhong Cui",

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AU - Lin, Yang

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AU - Zhang, Qifu

AU - Ye, Xiongying

AU - Cui, Tianhong

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N2 - This paper presents a simple and robust antifouling sensor based on a nano-wrinkle electrode with bovine serum albumin for electrochemically detecting small molecules in complex body fluids. The nano-wrinkle was prepared by a one-step shrinking technique, being capable of excluding large proteins in physical structures and enhancing the response of small molecules. The prepared sensor demonstrates excellent antifouling capability under discontinuous or continuous exposure to proteins or fetal calf serum, which preserves 97% of its original signal after a 21-day exposure to fetal calf serum and enabled the quantification of dopamine in the protein-coexisted environment with a low limit of detection (LOD) (1.09 μM) and a wide detection range from 20 to 1105 μM.

AB - This paper presents a simple and robust antifouling sensor based on a nano-wrinkle electrode with bovine serum albumin for electrochemically detecting small molecules in complex body fluids. The nano-wrinkle was prepared by a one-step shrinking technique, being capable of excluding large proteins in physical structures and enhancing the response of small molecules. The prepared sensor demonstrates excellent antifouling capability under discontinuous or continuous exposure to proteins or fetal calf serum, which preserves 97% of its original signal after a 21-day exposure to fetal calf serum and enabled the quantification of dopamine in the protein-coexisted environment with a low limit of detection (LOD) (1.09 μM) and a wide detection range from 20 to 1105 μM.

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Antifouling for Electrochemically Biosensing in Body Fluids

Abstract

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