Antiestrogen resistance and the application of systems biology

Kerrie B. Bouker, Yue Wang, Jianhua Xuan, Robert Clarke

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Understanding the molecular changes that drive an acquired antiestrogen resistance phenotype is of major clinical relevance. Previous methodologies for addressing this question have taken a single gene/pathway approach and the resulting gains have been limited in terms of their clinical impact. Recent systems biology approaches allow for the integration of data from high throughput '-omics' technologies. We highlight recent advances in the field of antiestrogen resistance with a focus on transcriptomics, proteomics and methylomics.

Original languageEnglish (US)
Pages (from-to)e11-e17
JournalDrug Discovery Today: Disease Mechanisms
Issue number1-2
StatePublished - Jun 2012
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported in part by awards from the US Department of Health and Human Services to Robert Clarke: R01-CA131465 and U54-CA149147. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.


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