Antidiuretic hormone excess

Aaron L. Friedman, William E. Segar

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Known physiologic mechanisms explain the elevatedblood ADH levels observed in most patients with the syndrome of inappropriate ADH. Therefore the word "inappropriate" is a misnomer. It implies that the mechanisms that regulate ADH release are not functioning normally-which is not true. The term misleads the physician who, ideally, should determine why a patient has an excessive blood ADH level and initiate appropriate treatment. Patients with ectopic production of ADH and hyponatremia should be so labeled: "Hyponatremia due to ectopic ADH production". The term SIADH, if used at all, should be reserved for the rare patient with CNS injury or disease that causes increased ADH release and in which the hypothalamic center does not respond normally to afferent peripheral stimuli.

Original languageEnglish (US)
Pages (from-to)521-526
Number of pages6
JournalThe Journal of pediatrics
Issue number4
StatePublished - Apr 1979
Externally publishedYes

Bibliographical note

Funding Information:
From the Department of Pediatrics, University of Wisconsin Center for Health Sciences. Supported in part by National Institutes of Health Grant No. HL13880 *Reprint address: Department of Pediatrics, 1300 University Ave., Madison, 14/1 53706.


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