Antidepressants alter cerebrovascular permeability and metabolic rate in primates

Sheldon H. Preskorn, Marcus E. Raichle, Boyd K Hartman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

External detection of the annihilation radiation produced by water labeled with oxygen-15 was used to measure cerebrovascular permeability and cerebral blood flow in six rhesus monkeys. Use of oxygen-15 also permitted assessment of cerebral metabolic rate in two of the monkeys. Amitriptyline produced a dose-dependent, reversible increase in permeability at plasma drug concentrations which are therapeutic for depressed patients. At the same concentrations the drug also produced a 20 to 30 percent reduction in cerebral metabolic rate. At higher doses normal autoregulation of cerebral blood flow was suspended, but responsivity to arterial carbon dioxide was normal.

Original languageEnglish (US)
Pages (from-to)250-252
Number of pages3
JournalScience
Volume217
Issue number4556
DOIs
StatePublished - Jan 1 1982

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Cerebrovascular Circulation
Primates
Antidepressive Agents
Permeability
Oxygen
Amitriptyline
Macaca mulatta
Carbon Dioxide
Pharmaceutical Preparations
Haplorhini
Homeostasis
Radiation
Water
Therapeutics

Cite this

Antidepressants alter cerebrovascular permeability and metabolic rate in primates. / Preskorn, Sheldon H.; Raichle, Marcus E.; Hartman, Boyd K.

In: Science, Vol. 217, No. 4556, 01.01.1982, p. 250-252.

Research output: Contribution to journalArticle

Preskorn, SH, Raichle, ME & Hartman, BK 1982, 'Antidepressants alter cerebrovascular permeability and metabolic rate in primates', Science, vol. 217, no. 4556, pp. 250-252. https://doi.org/10.1126/science.7089562
Preskorn, Sheldon H. ; Raichle, Marcus E. ; Hartman, Boyd K. / Antidepressants alter cerebrovascular permeability and metabolic rate in primates. In: Science. 1982 ; Vol. 217, No. 4556. pp. 250-252.
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