Antibodies against vesicular stomatitis virus in horses from southern, midwestern and northeastern Brazilian states

Vinícius Leobet Lunkes, Alexandre Alberto Tonin, Gustavo Machado, Luis Gustavo Corbellini, Gustavo Nogueira Diehl, Lucila Carboneiro dos Santos, Camila de Sousa Bezerra, Sérgio Santos de Azevedo, Nebson Fernandes Pequeno, Adriana Moraes da Silva, Rudi Weiblen, Eduardo Furtado Flores

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5 Scopus citations


Vesicular stomatitis virus (VSV) is the agent of a vesicular disease that affects many animal species and may be clinically confounded with foot-and-mouth disease in ruminant and swine. Horses are especially susceptible to VSV and may serve as sentinels for virus circulation. The present study investigated the presence of neutralizing antibodies against VSV Indiana III (VSIV-3) in serum samples of 3,626 horses from six states in three Brazilian regions: Southern (RS, n = 1,011), Midwest (GO/DF, n = 1,767) and Northeast (PB, PE, RN and CE, n = 848) collected between 2013 and 2014. Neutralizing antibodies against VSIV-3 (titers ≥40) were detected in 641 samples (positivity of 17.7%; CI95%:16.5-19.0%), being 317 samples from CE (87.3%; CI95%: 83.4-90.5%); 109 from RN (65.7%; CI95%: 57.8 -72.7%); 124 from PB (45.4%; CI95%: 39.4-51.5%); 78 from GO/DF (4.4%; CI95%: 3.5-5.5%) and nine samples of RS (0.9%; CI95%: 0.4-1.7%). Several samples from the Northeast and Midwest harbored high neutralizing titers, indicating a recent exposure to the virus. In contrast, samples from RS had low titers, possibly due to a past remote exposure. Several positive samples presented neutralizing activity against other VSV serotypes (Indiana I and New Jersey), yet in lower titers, indicating the specificity of the response to VSIV-3. These results demonstrated a relatively recent circulation of VSIV-3 in northeastern Brazilian States, confirming clinical findings and demonstrating the sanitary importance of this infection.

Original languageEnglish (US)
Pages (from-to)1424-1429
Number of pages6
JournalCiencia Rural
Issue number8
StatePublished - Aug 2016

Bibliographical note

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© 2016, Universidade Federal de Santa Maria. All Rights Reserved.


  • Differential diagnosis
  • Foot-and-mouth disease
  • Serology
  • Vesicular disease
  • Zoonosis


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