Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced swiss albino mice

Jalal Uddin Bhat; Qudsia Nizami; Asia Asiaf; Shabir Ahmad Parray; Shiekh Tanveer Ahmad; Mohammad Aslam; Razia Khanam; Mohammad Mujeeb; Sadiq Umar; Aisha Siddiqui

Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced swiss albino mice

Jalal Uddin Bhat, Qudsia Nizami, Asia Asiaf, Shabir Ahmad Parray, Shiekh Tanveer Ahmad, Mohammad Aslam, Razia Khanam, Mohammad Mujeeb, Sadiq Umar, Aisha Siddiqui

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

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Abstract

The aim of the present study was to evaluate the anticonvulsant effect of whole plant extracts of Melissa parviflora using MES and PTZ induced seizures models. The dried whole plant was subjected to extraction in methanol and water. The extracts were subjected to phytochemical tests and the carbohydrate, flavonols, coumarins, glycosides and steroid were found to be present. The methanolic and aqueous extracts of the plant of Melissa parviflora were observed for their anticonvulsant activity by Maximal Electroshock seizures (MES) test and Pentylene-tetrazole (PTZ) test using Swiss albino mice. Both the extracts showed significant activity in MES and PTZ induced convulsions in comparison to control. From the literature surveys as well experiments performed, it can be said that Melissa parviflora does pose anticonvulsant property.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	EXCLI Journal
Volume	11
State	Published - 2012

Keywords

Anticonvulsant effects
Maximal electroshock
Melissa parviflora
Pentylene-tetrazole

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title = "Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced swiss albino mice",

abstract = "The aim of the present study was to evaluate the anticonvulsant effect of whole plant extracts of Melissa parviflora using MES and PTZ induced seizures models. The dried whole plant was subjected to extraction in methanol and water. The extracts were subjected to phytochemical tests and the carbohydrate, flavonols, coumarins, glycosides and steroid were found to be present. The methanolic and aqueous extracts of the plant of Melissa parviflora were observed for their anticonvulsant activity by Maximal Electroshock seizures (MES) test and Pentylene-tetrazole (PTZ) test using Swiss albino mice. Both the extracts showed significant activity in MES and PTZ induced convulsions in comparison to control. From the literature surveys as well experiments performed, it can be said that Melissa parviflora does pose anticonvulsant property.",

keywords = "Anticonvulsant effects, Maximal electroshock, Melissa parviflora, Pentylene-tetrazole",

author = "Bhat, {Jalal Uddin} and Qudsia Nizami and Asia Asiaf and Parray, {Shabir Ahmad} and Ahmad, {Shiekh Tanveer} and Mohammad Aslam and Razia Khanam and Mohammad Mujeeb and Sadiq Umar and Aisha Siddiqui",

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language = "English (US)",

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AU - Bhat, Jalal Uddin

AU - Nizami, Qudsia

AU - Asiaf, Asia

AU - Parray, Shabir Ahmad

AU - Ahmad, Shiekh Tanveer

AU - Aslam, Mohammad

AU - Khanam, Razia

AU - Mujeeb, Mohammad

AU - Umar, Sadiq

AU - Siddiqui, Aisha

PY - 2012

Y1 - 2012

N2 - The aim of the present study was to evaluate the anticonvulsant effect of whole plant extracts of Melissa parviflora using MES and PTZ induced seizures models. The dried whole plant was subjected to extraction in methanol and water. The extracts were subjected to phytochemical tests and the carbohydrate, flavonols, coumarins, glycosides and steroid were found to be present. The methanolic and aqueous extracts of the plant of Melissa parviflora were observed for their anticonvulsant activity by Maximal Electroshock seizures (MES) test and Pentylene-tetrazole (PTZ) test using Swiss albino mice. Both the extracts showed significant activity in MES and PTZ induced convulsions in comparison to control. From the literature surveys as well experiments performed, it can be said that Melissa parviflora does pose anticonvulsant property.

AB - The aim of the present study was to evaluate the anticonvulsant effect of whole plant extracts of Melissa parviflora using MES and PTZ induced seizures models. The dried whole plant was subjected to extraction in methanol and water. The extracts were subjected to phytochemical tests and the carbohydrate, flavonols, coumarins, glycosides and steroid were found to be present. The methanolic and aqueous extracts of the plant of Melissa parviflora were observed for their anticonvulsant activity by Maximal Electroshock seizures (MES) test and Pentylene-tetrazole (PTZ) test using Swiss albino mice. Both the extracts showed significant activity in MES and PTZ induced convulsions in comparison to control. From the literature surveys as well experiments performed, it can be said that Melissa parviflora does pose anticonvulsant property.

KW - Anticonvulsant effects

KW - Maximal electroshock

KW - Melissa parviflora

KW - Pentylene-tetrazole

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SN - 1611-2156

VL - 11

SP - 1

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JO - EXCLI Journal

JF - EXCLI Journal

ER -

Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced swiss albino mice

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