Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced swiss albino mice

Jalal Uddin Bhat, Qudsia Nizami, Asia Asiaf, Shabir Ahmad Parray, Shiekh Tanveer Ahmad, Mohammad Aslam, Razia Khanam, Mohammad Mujeeb, Sadiq Umar, Aisha Siddiqui

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3 Scopus citations

Abstract

The aim of the present study was to evaluate the anticonvulsant effect of whole plant extracts of Melissa parviflora using MES and PTZ induced seizures models. The dried whole plant was subjected to extraction in methanol and water. The extracts were subjected to phytochemical tests and the carbohydrate, flavonols, coumarins, glycosides and steroid were found to be present. The methanolic and aqueous extracts of the plant of Melissa parviflora were observed for their anticonvulsant activity by Maximal Electroshock seizures (MES) test and Pentylene-tetrazole (PTZ) test using Swiss albino mice. Both the extracts showed significant activity in MES and PTZ induced convulsions in comparison to control. From the literature surveys as well experiments performed, it can be said that Melissa parviflora does pose anticonvulsant property.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalEXCLI Journal
Volume11
StatePublished - Oct 23 2012

Keywords

  • Anticonvulsant effects
  • Maximal electroshock
  • Melissa parviflora
  • Pentylene-tetrazole

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