Anticoagulation in COVID-19: A Systematic Review, Meta-analysis, and Rapid Guidance From Mayo Clinic

Robert D. McBane; Victor D. Torres Roldan; Alexander S. Niven; Rajiv K. Pruthi; Pablo Moreno Franco; Jane A. Linderbaum; Ana I. Casanegra; Lance J. Oyen; Damon E. Houghton; Ariela L. Marshall; Narith N. Ou; Jason L. Siegel; Waldemar E. Wysokinski; Leslie J. Padrnos; Candido E. Rivera; Gayle L. Flo; Fadi E. Shamoun; Scott M. Silvers; Tarek Nayfeh; Meritxell Urtecho; Sahrish Shah; Raed Benkhadra; Samer Mohir Saadi; Mohammed Firwana; Tabinda Jawaid; Mustapha Amin; Larry J. Prokop; M. Hassan Murad

doi:10.1016/j.mayocp.2020.08.030

Anticoagulation in COVID-19: A Systematic Review, Meta-analysis, and Rapid Guidance From Mayo Clinic

Robert D. McBane, Victor D. Torres Roldan, Alexander S. Niven, Rajiv K. Pruthi, Pablo Moreno Franco, Jane A. Linderbaum, Ana I. Casanegra, Lance J. Oyen, Damon E. Houghton, Ariela L. Marshall, Narith N. Ou, Jason L. Siegel, Waldemar E. Wysokinski, Leslie J. Padrnos, Candido E. Rivera, Gayle L. Flo, Fadi E. Shamoun, Scott M. Silvers, Tarek Nayfeh, Meritxell UrtechoSahrish Shah, Raed Benkhadra, Samer Mohir Saadi, Mohammed Firwana, Tabinda Jawaid, Mustapha Amin, Larry J. Prokop, M. Hassan Murad

Research output: Contribution to journal › Review article › peer-review

87 Scopus citations

Abstract

A higher risk of thrombosis has been described as a prominent feature of coronavirus disease 2019 (COVID-19). This systematic review synthesizes current data on thrombosis risk, prognostic implications, and anticoagulation effects in COVID-19. We included 37 studies from 4070 unique citations. Meta-analysis was performed when feasible. Coagulopathy and thrombotic events were frequent among patients with COVID-19 and further increased in those with more severe forms of the disease. We also present guidance on the prevention and management of thrombosis from a multidisciplinary panel of specialists from Mayo Clinic. The current certainty of evidence is generally very low and continues to evolve.

Original language	English (US)
Pages (from-to)	2467-2486
Number of pages	20
Journal	Mayo Clinic Proceedings
Volume	95
Issue number	11
DOIs	https://doi.org/10.1016/j.mayocp.2020.08.030
State	Published - Nov 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Mayo Foundation for Medical Education and Research

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McBane, R. D., Torres Roldan, V. D., Niven, A. S., Pruthi, R. K., Franco, P. M., Linderbaum, J. A., Casanegra, A. I., Oyen, L. J., Houghton, D. E., Marshall, A. L., Ou, N. N., Siegel, J. L., Wysokinski, W. E., Padrnos, L. J., Rivera, C. E., Flo, G. L., Shamoun, F. E., Silvers, S. M., Nayfeh, T., ... Murad, M. H. (2020). Anticoagulation in COVID-19: A Systematic Review, Meta-analysis, and Rapid Guidance From Mayo Clinic. Mayo Clinic Proceedings, 95(11), 2467-2486. https://doi.org/10.1016/j.mayocp.2020.08.030

McBane, RD, Torres Roldan, VD, Niven, AS, Pruthi, RK, Franco, PM, Linderbaum, JA, Casanegra, AI, Oyen, LJ, Houghton, DE, Marshall, AL, Ou, NN, Siegel, JL, Wysokinski, WE, Padrnos, LJ, Rivera, CE, Flo, GL, Shamoun, FE, Silvers, SM, Nayfeh, T, Urtecho, M, Shah, S, Benkhadra, R, Saadi, SM, Firwana, M, Jawaid, T, Amin, M, Prokop, LJ & Murad, MH 2020, 'Anticoagulation in COVID-19: A Systematic Review, Meta-analysis, and Rapid Guidance From Mayo Clinic', Mayo Clinic Proceedings, vol. 95, no. 11, pp. 2467-2486. https://doi.org/10.1016/j.mayocp.2020.08.030

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abstract = "A higher risk of thrombosis has been described as a prominent feature of coronavirus disease 2019 (COVID-19). This systematic review synthesizes current data on thrombosis risk, prognostic implications, and anticoagulation effects in COVID-19. We included 37 studies from 4070 unique citations. Meta-analysis was performed when feasible. Coagulopathy and thrombotic events were frequent among patients with COVID-19 and further increased in those with more severe forms of the disease. We also present guidance on the prevention and management of thrombosis from a multidisciplinary panel of specialists from Mayo Clinic. The current certainty of evidence is generally very low and continues to evolve.",

author = "McBane, {Robert D.} and {Torres Roldan}, {Victor D.} and Niven, {Alexander S.} and Pruthi, {Rajiv K.} and Franco, {Pablo Moreno} and Linderbaum, {Jane A.} and Casanegra, {Ana I.} and Oyen, {Lance J.} and Houghton, {Damon E.} and Marshall, {Ariela L.} and Ou, {Narith N.} and Siegel, {Jason L.} and Wysokinski, {Waldemar E.} and Padrnos, {Leslie J.} and Rivera, {Candido E.} and Flo, {Gayle L.} and Shamoun, {Fadi E.} and Silvers, {Scott M.} and Tarek Nayfeh and Meritxell Urtecho and Sahrish Shah and Raed Benkhadra and Saadi, {Samer Mohir} and Mohammed Firwana and Tabinda Jawaid and Mustapha Amin and Prokop, {Larry J.} and Murad, {M. Hassan}",

note = "Publisher Copyright: {\textcopyright} 2020 Mayo Foundation for Medical Education and Research",

year = "2020",

month = nov,

doi = "10.1016/j.mayocp.2020.08.030",

language = "English (US)",

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AU - Niven, Alexander S.

AU - Pruthi, Rajiv K.

AU - Franco, Pablo Moreno

AU - Linderbaum, Jane A.

AU - Casanegra, Ana I.

AU - Oyen, Lance J.

AU - Houghton, Damon E.

AU - Marshall, Ariela L.

AU - Ou, Narith N.

AU - Siegel, Jason L.

AU - Wysokinski, Waldemar E.

AU - Padrnos, Leslie J.

AU - Rivera, Candido E.

AU - Flo, Gayle L.

AU - Shamoun, Fadi E.

AU - Silvers, Scott M.

AU - Nayfeh, Tarek

AU - Urtecho, Meritxell

AU - Shah, Sahrish

AU - Benkhadra, Raed

AU - Saadi, Samer Mohir

AU - Firwana, Mohammed

AU - Jawaid, Tabinda

AU - Amin, Mustapha

AU - Prokop, Larry J.

AU - Murad, M. Hassan

PY - 2020/11

Y1 - 2020/11

N2 - A higher risk of thrombosis has been described as a prominent feature of coronavirus disease 2019 (COVID-19). This systematic review synthesizes current data on thrombosis risk, prognostic implications, and anticoagulation effects in COVID-19. We included 37 studies from 4070 unique citations. Meta-analysis was performed when feasible. Coagulopathy and thrombotic events were frequent among patients with COVID-19 and further increased in those with more severe forms of the disease. We also present guidance on the prevention and management of thrombosis from a multidisciplinary panel of specialists from Mayo Clinic. The current certainty of evidence is generally very low and continues to evolve.

AB - A higher risk of thrombosis has been described as a prominent feature of coronavirus disease 2019 (COVID-19). This systematic review synthesizes current data on thrombosis risk, prognostic implications, and anticoagulation effects in COVID-19. We included 37 studies from 4070 unique citations. Meta-analysis was performed when feasible. Coagulopathy and thrombotic events were frequent among patients with COVID-19 and further increased in those with more severe forms of the disease. We also present guidance on the prevention and management of thrombosis from a multidisciplinary panel of specialists from Mayo Clinic. The current certainty of evidence is generally very low and continues to evolve.

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Anticoagulation in COVID-19: A Systematic Review, Meta-analysis, and Rapid Guidance From Mayo Clinic

Abstract

Bibliographical note

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