Antibody Response in the Rat II. Microclasmatosis, a Possible Mode of Antibody Release

Seong S. Han; Ihn H. Han; Arthur G. Johnson

doi:10.3181/00379727-121-30886

Antibody Response in the Rat II. Microclasmatosis, a Possible Mode of Antibody Release

Seong S. Han, Ihn H. Han, Arthur G. Johnson

Biomedical Sciences

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Abstract

Electron microscopic observations were made of cells in spleens taken from Sprague-Dawley rats during the primary antibody response to bovine gamma globulin. Many of the resulting plasma cells were found to produce a series of vesicles by membrane invaginations which surrounded small pieces of the rough-surfaced endoplasmic reticulum (RER). By coalescence of these vesicles, chunks of cytoplasm containing the RER appeared to be liberated from the plasmacytic cells. The process, microclasmatosis, was postulated to represent one physiological way of release and transport of formed antibody globulins.

Original language	English (US)
Pages (from-to)	782-785
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	121
Issue number	3
DOIs	https://doi.org/10.3181/00379727-121-30886
State	Published - Mar 1966

Bibliographical note

Funding Information:
This study was supported by USPHS Grant E 1524 and Am. Cancer Soc. Grant IN 40 D. 3 1966 121 3 782 785

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abstract = "Electron microscopic observations were made of cells in spleens taken from Sprague-Dawley rats during the primary antibody response to bovine gamma globulin. Many of the resulting plasma cells were found to produce a series of vesicles by membrane invaginations which surrounded small pieces of the rough-surfaced endoplasmic reticulum (RER). By coalescence of these vesicles, chunks of cytoplasm containing the RER appeared to be liberated from the plasmacytic cells. The process, microclasmatosis, was postulated to represent one physiological way of release and transport of formed antibody globulins.",

author = "Han, {Seong S.} and Han, {Ihn H.} and Johnson, {Arthur G.}",

note = "Funding Information: This study was supported by USPHS Grant E 1524 and Am. Cancer Soc. Grant IN 40 D. 3 1966 121 3 782 785 ",

year = "1966",

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doi = "10.3181/00379727-121-30886",

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AU - Johnson, Arthur G.

N1 - Funding Information: This study was supported by USPHS Grant E 1524 and Am. Cancer Soc. Grant IN 40 D. 3 1966 121 3 782 785

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N2 - Electron microscopic observations were made of cells in spleens taken from Sprague-Dawley rats during the primary antibody response to bovine gamma globulin. Many of the resulting plasma cells were found to produce a series of vesicles by membrane invaginations which surrounded small pieces of the rough-surfaced endoplasmic reticulum (RER). By coalescence of these vesicles, chunks of cytoplasm containing the RER appeared to be liberated from the plasmacytic cells. The process, microclasmatosis, was postulated to represent one physiological way of release and transport of formed antibody globulins.

AB - Electron microscopic observations were made of cells in spleens taken from Sprague-Dawley rats during the primary antibody response to bovine gamma globulin. Many of the resulting plasma cells were found to produce a series of vesicles by membrane invaginations which surrounded small pieces of the rough-surfaced endoplasmic reticulum (RER). By coalescence of these vesicles, chunks of cytoplasm containing the RER appeared to be liberated from the plasmacytic cells. The process, microclasmatosis, was postulated to represent one physiological way of release and transport of formed antibody globulins.

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Antibody Response in the Rat II. Microclasmatosis, a Possible Mode of Antibody Release

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