Electron microscopic observations were made of cells in spleens taken from Sprague-Dawley rats during the primary antibody response to bovine gamma globulin. Many of the resulting plasma cells were found to produce a series of vesicles by membrane invaginations which surrounded small pieces of the rough-surfaced endoplasmic reticulum (RER). By coalescence of these vesicles, chunks of cytoplasm containing the RER appeared to be liberated from the plasmacytic cells. The process, microclasmatosis, was postulated to represent one physiological way of release and transport of formed antibody globulins.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Mar 1966|
Bibliographical noteFunding Information:
This study was supported by USPHS Grant E 1524 and Am. Cancer Soc. Grant IN 40 D. 3 1966 121 3 782 785