Antibodies to GM1 and GD1b in patients with motor neuron disease without plasma cell dyscrasia

Michael E. Shy; Vance A. Evans; Fred D. Lublin; Robert L. Knobler; Terry Heiman‐Patterson; Albert J. Tahmoush; Gareth Parry; Paul Schick; Theodora G. Deryk

doi:10.1002/ana.410250517

Antibodies to GM₁ and GD_1b in patients with motor neuron disease without plasma cell dyscrasia

Michael E. Shy, Vance A. Evans, Fred D. Lublin, Robert L. Knobler, Terry Heiman‐Patterson, Albert J. Tahmoush, Gareth Parry, Paul Schick, Theodora G. Deryk

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72 Scopus citations

Abstract

Fiftynine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM₁ but usually not to GD_1b at titers less than 1:80. This suggests that antibodies to GM₁ may be part of the normal human antibody repertoire. However, given the higher incidence of antibodies to GM₁ in patients with motor neuron disease, there may be specific epitopes important in antiganglioside antibodies associated with motor neuron disease.

Original language	English (US)
Pages (from-to)	511-513
Number of pages	3
Journal	Annals of Neurology
Volume	25
Issue number	5
DOIs	https://doi.org/10.1002/ana.410250517
State	Published - May 1989
Externally published	Yes

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title = "Antibodies to GM1 and GD1b in patients with motor neuron disease without plasma cell dyscrasia",

abstract = "Fiftynine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM1 but usually not to GD1b at titers less than 1:80. This suggests that antibodies to GM1 may be part of the normal human antibody repertoire. However, given the higher incidence of antibodies to GM1 in patients with motor neuron disease, there may be specific epitopes important in antiganglioside antibodies associated with motor neuron disease.",

author = "Shy, {Michael E.} and Evans, {Vance A.} and Lublin, {Fred D.} and Knobler, {Robert L.} and Terry Heiman‐Patterson and Tahmoush, {Albert J.} and Gareth Parry and Paul Schick and Deryk, {Theodora G.}",

year = "1989",

month = may,

doi = "10.1002/ana.410250517",

language = "English (US)",

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T1 - Antibodies to GM1 and GD1b in patients with motor neuron disease without plasma cell dyscrasia

AU - Shy, Michael E.

AU - Evans, Vance A.

AU - Lublin, Fred D.

AU - Knobler, Robert L.

AU - Heiman‐Patterson, Terry

AU - Tahmoush, Albert J.

AU - Parry, Gareth

AU - Schick, Paul

AU - Deryk, Theodora G.

PY - 1989/5

Y1 - 1989/5

N2 - Fiftynine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM1 but usually not to GD1b at titers less than 1:80. This suggests that antibodies to GM1 may be part of the normal human antibody repertoire. However, given the higher incidence of antibodies to GM1 in patients with motor neuron disease, there may be specific epitopes important in antiganglioside antibodies associated with motor neuron disease.

AB - Fiftynine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM1 but usually not to GD1b at titers less than 1:80. This suggests that antibodies to GM1 may be part of the normal human antibody repertoire. However, given the higher incidence of antibodies to GM1 in patients with motor neuron disease, there may be specific epitopes important in antiganglioside antibodies associated with motor neuron disease.

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JO - Annals of Neurology

JF - Annals of Neurology

IS - 5

ER -

Antibodies to GM₁ and GD_1b in patients with motor neuron disease without plasma cell dyscrasia

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