Antibodies to cerebroside sulfate inhibit the effects of morphine and β-endorphin

Frederick B. Craves; Boris Zalc; Leonid Leybin; Nicole Baumann; Horace H. Loh

doi:10.1126/science.6243189

Antibodies to cerebroside sulfate inhibit the effects of morphine and β-endorphin

Frederick B. Craves, Boris Zalc, Leonid Leybin, Nicole Baumann, Horace H. Loh

Pharmacology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Morphine and β-endorphin inhibit the shaking response of pentobarbital-anesthetized rats to ice water. Stereotaxically guided administration of antibodies to cerebroside sulfate into the periaqueductal gray region, the most sensitive brain region in which to demonstrate inhibition of this response, antagonizes the effect of morphine and β-endorphin. These results suggest that cerebroside sulfate may be an integral component of an opiate receptor in rat brain.

Original language	English (US)
Pages (from-to)	75-76
Number of pages	2
Journal	Science
Volume	207
Issue number	4426
DOIs	https://doi.org/10.1126/science.6243189
State	Published - 1980

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abstract = "Morphine and β-endorphin inhibit the shaking response of pentobarbital-anesthetized rats to ice water. Stereotaxically guided administration of antibodies to cerebroside sulfate into the periaqueductal gray region, the most sensitive brain region in which to demonstrate inhibition of this response, antagonizes the effect of morphine and β-endorphin. These results suggest that cerebroside sulfate may be an integral component of an opiate receptor in rat brain.",

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T1 - Antibodies to cerebroside sulfate inhibit the effects of morphine and β-endorphin

AU - Craves, Frederick B.

AU - Zalc, Boris

AU - Leybin, Leonid

AU - Baumann, Nicole

AU - Loh, Horace H.

PY - 1980

Y1 - 1980

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AB - Morphine and β-endorphin inhibit the shaking response of pentobarbital-anesthetized rats to ice water. Stereotaxically guided administration of antibodies to cerebroside sulfate into the periaqueductal gray region, the most sensitive brain region in which to demonstrate inhibition of this response, antagonizes the effect of morphine and β-endorphin. These results suggest that cerebroside sulfate may be an integral component of an opiate receptor in rat brain.

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JO - Science

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ER -

Antibodies to cerebroside sulfate inhibit the effects of morphine and β-endorphin

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