Antibodies to cerebroside sulfate inhibit the effects of morphine and β-endorphin

Frederick B. Craves, Boris Zalc, Leonid Leybin, Nicole Baumann, Horace H. Loh

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Morphine and β-endorphin inhibit the shaking response of pentobarbital-anesthetized rats to ice water. Stereotaxically guided administration of antibodies to cerebroside sulfate into the periaqueductal gray region, the most sensitive brain region in which to demonstrate inhibition of this response, antagonizes the effect of morphine and β-endorphin. These results suggest that cerebroside sulfate may be an integral component of an opiate receptor in rat brain.

Original languageEnglish (US)
Pages (from-to)75-76
Number of pages2
JournalScience
Volume207
Issue number4426
DOIs
StatePublished - Jan 1 1980

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