Antibodies to ACTH in opsoclonus-myoclonus

M. R. Pranzatelli; P. C. Kao; E. D. Tate; E. Chaves; M. Chez; W. B. Dobyns; H. Kang; D. A. Rothner

doi:10.1055/s-2008-1071529

Antibodies to ACTH in opsoclonus-myoclonus

M. R. Pranzatelli, P. C. Kao, E. D. Tate, E. Chaves, M. Chez, W. B. Dobyns, H. Kang, D. A. Rothner

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Antibodies to ACTH_1-24 detected by radioimmunoassay were present in the serum of a child with opsoclonus-myoclonus for at least 24 weeks after discontinuation of chronic ACTH treatment. The antibody-bound ACTH did not interfere with cortisol secretion. Six other children with opsoclonus-myoclonus and 16 control sera, including patients with chronically elevated endogenous ACTH, did not exhibit autoantibodies to ACTH. Antibodies to ACTH should be sought in patients who develop tolerance to ACTH treatment. The indirect but not direct ACTH assay method is sensitive to the presence of ACTH antibodies.

Original language	English (US)
Pages (from-to)	131-133
Number of pages	3
Journal	Neuropediatrics
Volume	24
Issue number	3
DOIs	https://doi.org/10.1055/s-2008-1071529
State	Published - 1993
Externally published	Yes

Keywords

ACTH
ACTH antibodies
Opsoclonus-myoclonus

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10.1055/s-2008-1071529

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title = "Antibodies to ACTH in opsoclonus-myoclonus",

abstract = "Antibodies to ACTH1-24 detected by radioimmunoassay were present in the serum of a child with opsoclonus-myoclonus for at least 24 weeks after discontinuation of chronic ACTH treatment. The antibody-bound ACTH did not interfere with cortisol secretion. Six other children with opsoclonus-myoclonus and 16 control sera, including patients with chronically elevated endogenous ACTH, did not exhibit autoantibodies to ACTH. Antibodies to ACTH should be sought in patients who develop tolerance to ACTH treatment. The indirect but not direct ACTH assay method is sensitive to the presence of ACTH antibodies.",

keywords = "ACTH, ACTH antibodies, Opsoclonus-myoclonus",

author = "Pranzatelli, {M. R.} and Kao, {P. C.} and Tate, {E. D.} and E. Chaves and M. Chez and Dobyns, {W. B.} and H. Kang and Rothner, {D. A.}",

year = "1993",

doi = "10.1055/s-2008-1071529",

language = "English (US)",

volume = "24",

pages = "131--133",

journal = "Neuropediatrics",

issn = "0174-304X",

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TY - JOUR

T1 - Antibodies to ACTH in opsoclonus-myoclonus

AU - Pranzatelli, M. R.

AU - Kao, P. C.

AU - Tate, E. D.

AU - Chaves, E.

AU - Chez, M.

AU - Dobyns, W. B.

AU - Kang, H.

AU - Rothner, D. A.

PY - 1993

Y1 - 1993

N2 - Antibodies to ACTH1-24 detected by radioimmunoassay were present in the serum of a child with opsoclonus-myoclonus for at least 24 weeks after discontinuation of chronic ACTH treatment. The antibody-bound ACTH did not interfere with cortisol secretion. Six other children with opsoclonus-myoclonus and 16 control sera, including patients with chronically elevated endogenous ACTH, did not exhibit autoantibodies to ACTH. Antibodies to ACTH should be sought in patients who develop tolerance to ACTH treatment. The indirect but not direct ACTH assay method is sensitive to the presence of ACTH antibodies.

AB - Antibodies to ACTH1-24 detected by radioimmunoassay were present in the serum of a child with opsoclonus-myoclonus for at least 24 weeks after discontinuation of chronic ACTH treatment. The antibody-bound ACTH did not interfere with cortisol secretion. Six other children with opsoclonus-myoclonus and 16 control sera, including patients with chronically elevated endogenous ACTH, did not exhibit autoantibodies to ACTH. Antibodies to ACTH should be sought in patients who develop tolerance to ACTH treatment. The indirect but not direct ACTH assay method is sensitive to the presence of ACTH antibodies.

KW - ACTH

KW - ACTH antibodies

KW - Opsoclonus-myoclonus

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U2 - 10.1055/s-2008-1071529

DO - 10.1055/s-2008-1071529

M3 - Article

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AN - SCOPUS:0027227407

SN - 0174-304X

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SP - 131

EP - 133

JO - Neuropediatrics

JF - Neuropediatrics

IS - 3

ER -

Antibodies to ACTH in opsoclonus-myoclonus

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