Antibodies to ACTH in opsoclonus-myoclonus

M. R. Pranzatelli, P. C. Kao, E. D. Tate, E. Chaves, M. Chez, W. B. Dobyns, H. Kang, D. A. Rothner

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8 Scopus citations

Abstract

Antibodies to ACTH1-24 detected by radioimmunoassay were present in the serum of a child with opsoclonus-myoclonus for at least 24 weeks after discontinuation of chronic ACTH treatment. The antibody-bound ACTH did not interfere with cortisol secretion. Six other children with opsoclonus-myoclonus and 16 control sera, including patients with chronically elevated endogenous ACTH, did not exhibit autoantibodies to ACTH. Antibodies to ACTH should be sought in patients who develop tolerance to ACTH treatment. The indirect but not direct ACTH assay method is sensitive to the presence of ACTH antibodies.

Original languageEnglish (US)
Pages (from-to)131-133
Number of pages3
JournalNeuropediatrics
Volume24
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • ACTH antibodies
  • ACTH
  • Opsoclonus-myoclonus

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