Antibacterial synergy of glycerol monolaurate and aminoglycosides in Staphylococcus aureus biofilms

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Abstract

Glycerol monolaurate (GML) is a natural surfactant with antimicrobial properties. At ∼0.3 mM, both GML and its component lauric acid were bactericidal for antibiotic-resistant Staphylococcus aureus biofilms. With the use of MICs of antibiotics obtained from planktonic cells, GML and lauric acid acted synergistically with gentamicin and streptomycin, but not ampicillin or vancomycin, to eliminate detectable viable biofilm bacteria. Images of GML-treated biofilms suggested that GML may facilitate antibiotic interaction with matrix-embedded bacteria.

Original languageEnglish (US)
Pages (from-to)6970-6973
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number11
DOIs
StatePublished - Nov 1 2014

Bibliographical note

Publisher Copyright:
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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