Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase

Keyphrases

• Viral 100%
• Protein Kinase 100%
• NS5A 100%
• Anti-apoptotic 100%
• Hepatitis C Virus 100%
• Oncogenic Potential 100%
• Interferon Resistance 100%
• Interferon-α (IFN-α) 80%
• Phosphorylation 20%
• Apoptosis 20%
• Vesicular Stomatitis Virus 20%
• Viral Gene Expression 20%
• Double-stranded RNA 20%
• Virus Resistance 20%
• Resistance to Interferon 20%
• Transformed Phenotype 10%
• Solid Tumors 10%
• Tumor Suppressor 10%
• Virus Persistence 10%
• Liver Dysfunction 10%
• Resistant Strains 10%
• Hepatocellular Carcinoma 10%
• Host Cell 10%
• Antiviral Response 10%
• Mammalian Cells 10%
• Therapeutic Regimen 10%
• High Prevalence 10%
• Apoptosis Inhibition 10%
• Anti-hepatitis C Virus 10%
• Ligand-binding Domain 10%
• Binding Function 10%
• Resistant Phenotypes 10%
• Interferon Therapy 10%
• Apoptotic Response 10%
• PKR Activation 10%
• Antiviral Action 10%
• MRNA Translation 10%
• Host Signaling 10%

Immunology and Microbiology

• Interferon Type I 100%
• Hepatitis C Virus 100%
• Kinase 100%
• Phosphotransferase 100%
• RNA Translation 25%
• Programmed Cell Death 25%
• Vesiculovirus 16%
• Double-Stranded RNA 16%
• phosphorylation 16%
• Infectious Disease 8%
• Prevalence 8%
• Host Cell 8%
• Mediator 8%
• Initiation Factor 2 8%
• Virus Resistance 8%
• Signal Transduction 8%
• Infection 8%
• Resistant Strain 8%