Anti-Yo positive paraneoplastic cerebellar degeneration in the setting of cholangiocarcinoma

Aubree Bruhnding, Derek Notch, Albertine S Beard

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Paraneoplastic neurological syndromes are a rare complication of malignancy. Subacute cerebellar ataxia, or paraneoplastic cerebellar degeneration, usually presents in women with a subcate onset of gait instability, followed by progressive limb and trunk ataxia, dysarthria, diplopia, and dysphagia that occurs in the setting of, or precedes the diagnosis of, a gynecologic or breast malignancy and clinically stabilizes within six months. The most common autoantibody associated with PCD is purkinje cell cytoplasmic antibody type 1, also known as anti-Yo. Here we describe the first reported case of a man with anti-Yo positive paraneoplastic cerebellar degeneration in the setting of occult cholangiocarcinoma.

Original languageEnglish (US)
Pages (from-to)71-72
Number of pages2
JournalJournal of Clinical Neuroscience
Volume36
DOIs
StatePublished - Feb 1 2017

Keywords

  • Anti-Yo
  • Anti-purkinje cytoplasmic antibody
  • Cholangiocarcinmoa
  • Paraneoplastic cerebellar degeneration

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