Anti-tumor activity of Korean Oldenlandiae Herba and Radix

Hyo Jeong Lee, Eun Ok Lee, Yun Hee Rhee, Kwan Hyun Kim, Jae Ho Lee, Nam In Baek, Jeong Chan Ra, Sung Hoon Kim

Research output: Contribution to journalArticlepeer-review

Abstract

For the evaluation of anti-tumor activity of Korean Oldenlandia Herb (KOH) and Radix (KOR), our experiment was performed with methanol extracts of KOH and KOR. They did not shown any cytotoxicity against HT1080 cell lines. However, they effectively showed anti-metastatic activity through inhibition of the adhesion of HT1080 cells to gelatin, downregulated the expression of MMP2 and uPA and upregulated the expression of TIMP2. They also inhibited tube formation of HUVECs induced by bFGF. However, they did not affect DNA topoisomerase I activity. Simiarly, the T/Cs % in KOH and KOR treated mice were increased 134.9% and 171%, respectively at 2500 mg/kg. These results suggest that KOH and KOR exert anti-tumor activity via anti-metastatic and anti-angiogenic activities. The further study for isolation of effective compounds and its exact mechanism and comparative study with Chinese Oldenlandia Herba will be required.

Original languageEnglish (US)
Pages (from-to)110-115
Number of pages6
JournalKorean Journal of Pharmacognosy
Volume35
Issue number2
StatePublished - Jun 2004
Externally publishedYes

Keywords

  • Adhesion
  • Anti-tumor
  • Herba
  • Korean
  • MMP2
  • Oldenlandia diffusa
  • Radix
  • S-180
  • TIMP2
  • Tube formation
  • UPA

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