Anti-T-Cell reagents for human bone marrow transplantation: Ricin linked to three monoclonal antibodies

Daniel A Vallera, Robert C. Ash, Esmail D. Zanjani, John H. Kersey, Tucker W LeBien, Peter C.L. Beverley, David M. Neville, Richard J. Youle

Research output: Contribution to journalArticlepeer-review

111 Scopus citations

Abstract

Three new reagents that react against human T cells were synthesized by covalently linking the toxin ricin to monoclonal antibodies recognizing differentiation antigens on the surface of T lymphocytes. Each of these immunotoxins selectively inhibited T-cell proliferation when the cells were incubated in the presence of lactose. Multipotent human stem cells were inhibited only at much higher concentrations. Mixtures of all three immunotoxins were more effective than any one alone. These reagents have the potential for preventing graft-versus-host disease in man.

Original languageEnglish (US)
Pages (from-to)512-515
Number of pages4
JournalScience
Volume222
Issue number4623
DOIs
StatePublished - 1983

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