Anti-staphylococcal activity of a penem, Sch 29482.

L. D. Sabath, M. Munyan, P. Mach

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Sch 29482 (SCH), a new broad-spectrum beta-lactam antibiotic, was studied in an in-vitro microtitre system using Mueller-Hinton broth for determining its antistaphylococcal activity. Each of the 68 isolates of staphylococci studied belonged to one of the following six groups, and had the median penem MIC values as noted in parentheses: penicillinase-positive (0.25 mg/l), or -negative (0.25 mg/l) Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (32 mg/l), or coagulase-negative staphylococci (128 mg/l), 'tolerant' Staph. aureus (0.012 mg/l), or methicillin-sensitive coagulase-negative staphylococci (
Original languageUndefined/Unknown
Pages (from-to)189-194
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Issue numberSuppl.C
StatePublished - 1982


  • animal experiment
  • drug comparison
  • drug response
  • drug sensitivity
  • in vitro study
  • Staphylococcus aureus
  • 2 ethylthio 6 (1 hydroxyethyl)penem 3 carboxylic acid
  • ampicillin
  • cefalexin
  • cefalotin
  • cefamandole
  • cephalosporin derivative
  • meticillin
  • nafcillin
  • penem derivative
  • penicillin derivative
  • penicillin K

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