Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model

Alexey O. Benyumov; Taracad K. Venkatachalam; Olga O. Grigoriants; Alexei O. Vassilev; Heather E. Tibbles; Suzanne Downs; Darin Dumez; Fatih M. Uckun

doi:10.1055/s-0031-1296832

Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model

Alexey O. Benyumov
, Taracad K. Venkatachalam
, Olga O. Grigoriants
, Alexei O. Vassilev
, Heather E. Tibbles
, Suzanne Downs
, Darin Dumez
, Fatih M. Uckun

Pulmonary, Allergy, Critical Care and Sleep Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryonic development followed by total cell fusion. DDE46 also inhibited the proliferation of the leukemic cell lines NALM-6 and MOLT-3. DDE46 enhanced the activity of the pro-apoptotic enzymes Caspase-3, Caspase-6, Caspase-8, and Caspase-9 leading to the apoptotic death of the leukemic cell line Jurkat. These results justify the further development of this agent as a new anti-leukemic drug candidate.

Original language	English (US)
Pages (from-to)	114-122
Number of pages	9
Journal	Arzneimittel-Forschung/Drug Research
Volume	55
Issue number	2
DOIs	https://doi.org/10.1055/s-0031-1296832
State	Published - 2005

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CAS 213982-96-8
DDE46, antileukemic activity, apoptosis, Zebrafish model
Zidovudine, bromomethoxylated arylphosphate derivative

Publisher link

10.1055/s-0031-1296832

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Benyumov, A. O., Venkatachalam, T. K., Grigoriants, O. O., Vassilev, A. O., Tibbles, H. E., Downs, S., Dumez, D., & Uckun, F. M. (2005). Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model. Arzneimittel-Forschung/Drug Research, 55(2), 114-122. https://doi.org/10.1055/s-0031-1296832

Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model. / Benyumov, Alexey O.; Venkatachalam, Taracad K.; Grigoriants, Olga O. et al.
In: Arzneimittel-Forschung/Drug Research, Vol. 55, No. 2, 2005, p. 114-122.

Research output: Contribution to journal › Article › peer-review

Benyumov, AO, Venkatachalam, TK, Grigoriants, OO, Vassilev, AO, Tibbles, HE, Downs, S, Dumez, D & Uckun, FM 2005, 'Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model', Arzneimittel-Forschung/Drug Research, vol. 55, no. 2, pp. 114-122. https://doi.org/10.1055/s-0031-1296832

Benyumov AO, Venkatachalam TK, Grigoriants OO, Vassilev AO, Tibbles HE, Downs S et al. Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model. Arzneimittel-Forschung/Drug Research. 2005;55(2):114-122. doi: 10.1055/s-0031-1296832

Benyumov, Alexey O. ; Venkatachalam, Taracad K. ; Grigoriants, Olga O. et al. / Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds : Studies using human acute lymphoblastic leukemia cells and the zebrafish model. In: Arzneimittel-Forschung/Drug Research. 2005 ; Vol. 55, No. 2. pp. 114-122.

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abstract = "The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryonic development followed by total cell fusion. DDE46 also inhibited the proliferation of the leukemic cell lines NALM-6 and MOLT-3. DDE46 enhanced the activity of the pro-apoptotic enzymes Caspase-3, Caspase-6, Caspase-8, and Caspase-9 leading to the apoptotic death of the leukemic cell line Jurkat. These results justify the further development of this agent as a new anti-leukemic drug candidate.",

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AU - Grigoriants, Olga O.

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AU - Tibbles, Heather E.

AU - Downs, Suzanne

AU - Dumez, Darin

AU - Uckun, Fatih M.

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Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model

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