Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model

Alexey O. Benyumov; Taracad K. Venkatachalam; Olga O. Grigoriants; Alexei O. Vassilev; Heather E. Tibbles; Suzanne Downs; Darin Dumez; Fatih M. Uckun

Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model

Alexey O. Benyumov, Taracad K. Venkatachalam, Olga O. Grigoriants, Alexei O. Vassilev, Heather E. Tibbles, Suzanne Downs, Darin Dumez, Fatih M. Uckun

Pulmonary, Allergy, Critical Care and Sleep Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryonic development followed by total cell fusion. DDE46 also inhibited the proliferation of the leukemic cell lines NALM-6 and MOLT-3. DDE46 enhanced the activity of the pro-apoptotic enzymes Caspase-3, Caspase-6, Caspase-8, and Caspase-9 leading to the apoptotic death of the leukemic cell line Jurkat. These results justify the further development of this agent as a new anti-leukemic drug candidate.

Original language	English (US)
Pages (from-to)	114-122
Number of pages	9
Journal	Arzneimittel-Forschung/Drug Research
Volume	55
Issue number	2
State	Published - Mar 17 2005

Keywords

CAS 213982-96-8
DDE46, antileukemic activity, apoptosis, Zebrafish model
Zidovudine, bromomethoxylated arylphosphate derivative

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Benyumov, A. O., Venkatachalam, T. K., Grigoriants, O. O., Vassilev, A. O., Tibbles, H. E., Downs, S., Dumez, D., & Uckun, F. M. (2005). Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model. Arzneimittel-Forschung/Drug Research, 55(2), 114-122.

Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds : Studies using human acute lymphoblastic leukemia cells and the zebrafish model. / Benyumov, Alexey O.; Venkatachalam, Taracad K.; Grigoriants, Olga O.; Vassilev, Alexei O.; Tibbles, Heather E.; Downs, Suzanne; Dumez, Darin; Uckun, Fatih M.

In: Arzneimittel-Forschung/Drug Research, Vol. 55, No. 2, 17.03.2005, p. 114-122.

Research output: Contribution to journal › Article › peer-review

Benyumov, AO, Venkatachalam, TK, Grigoriants, OO, Vassilev, AO, Tibbles, HE, Downs, S, Dumez, D & Uckun, FM 2005, 'Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model', Arzneimittel-Forschung/Drug Research, vol. 55, no. 2, pp. 114-122.

Benyumov AO, Venkatachalam TK, Grigoriants OO, Vassilev AO, Tibbles HE, Downs S et al. Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model. Arzneimittel-Forschung/Drug Research. 2005 Mar 17;55(2):114-122.

Benyumov, Alexey O. ; Venkatachalam, Taracad K. ; Grigoriants, Olga O. ; Vassilev, Alexei O. ; Tibbles, Heather E. ; Downs, Suzanne ; Dumez, Darin ; Uckun, Fatih M. / Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds : Studies using human acute lymphoblastic leukemia cells and the zebrafish model. In: Arzneimittel-Forschung/Drug Research. 2005 ; Vol. 55, No. 2. pp. 114-122.

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abstract = "The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryonic development followed by total cell fusion. DDE46 also inhibited the proliferation of the leukemic cell lines NALM-6 and MOLT-3. DDE46 enhanced the activity of the pro-apoptotic enzymes Caspase-3, Caspase-6, Caspase-8, and Caspase-9 leading to the apoptotic death of the leukemic cell line Jurkat. These results justify the further development of this agent as a new anti-leukemic drug candidate.",

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AU - Venkatachalam, Taracad K.

AU - Grigoriants, Olga O.

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AU - Dumez, Darin

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Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model

Abstract

Keywords

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