Abstract
The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryonic development followed by total cell fusion. DDE46 also inhibited the proliferation of the leukemic cell lines NALM-6 and MOLT-3. DDE46 enhanced the activity of the pro-apoptotic enzymes Caspase-3, Caspase-6, Caspase-8, and Caspase-9 leading to the apoptotic death of the leukemic cell line Jurkat. These results justify the further development of this agent as a new anti-leukemic drug candidate.
Original language | English (US) |
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Pages (from-to) | 114-122 |
Number of pages | 9 |
Journal | Arzneimittel-Forschung/Drug Research |
Volume | 55 |
Issue number | 2 |
State | Published - Mar 17 2005 |
Keywords
- CAS 213982-96-8
- DDE46, antileukemic activity, apoptosis, Zebrafish model
- Zidovudine, bromomethoxylated arylphosphate derivative