Anti-poliovirus activity of Nerium oleander aqueous extract

Giuseppina Sanna, Silvia Madeddu, Alessandra Serra, David Collu, Thomas Efferth, F. Lukmanul Hakkim, Luay Rashan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Nerium oleander (NO), a member of the Apocynaceae family, is an ornamental plant. In this study, we evaluated the antiviral activity of hot and cold extract of NO against six different viruses such as herpes simplex virus type 1 (HSV-1), polio virus type 1 (Sb-1), vesicular stomatitis virus (VSV), reovirus type-1 (Reo-1), human immunodeficiency virus type-1 (HIV-1), and yellow fever virus (YFV). Interestingly the results of plaque reduction assay demonstrated that both, hot extract and cold extract (breastin) of NO inhibited Sb-1 viral infection. In order to identify the mechanism by which NO exerts its antiviral activity, the virucidal effect, the time of addition and the adsorption assay were carried out. Results demonstrated that NO exerts its effect after infection period, particularly during the first two hours post infection.

Original languageEnglish (US)
Pages (from-to)633-636
Number of pages4
JournalNatural Product Research
Issue number4
StatePublished - 2021

Bibliographical note

Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.


  • Apocynaceae
  • Nerium oleander
  • antiviral activity
  • cold extract
  • hot extract
  • poliovirus


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