Anti-HIV-1 activity of trim 37

Azah A. Tabah, Keith Tardif, Louis M. Mansky

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Trim 5a was the first member of the tripartite motif (TRIM) family of proteins that was identified to potently restrict human immunodeficiency virus type 1 (HIV-1) replication. The breadth of antiretroviral activity of TRIM family members is an active area of investigation. In this study, we demonstrate that human Trim 37 possesses anti-HIV-1 activity. This antiretroviral activity and the manner in which it was displayed were implicated by (1) decreased viral replication upon Trim 37 transient overexpression in virus-producing cells, (2) correlation of the reduction of viral infectivity with Trim 37 virion incorporation, (3) increased HIV-1 replication during siRNA depletion of Trim 37 expression, and (4) reduction in viral DNA synthesis upon Trim 37 transient overexpression. Our findings provide the first demonstration, to our knowledge, of the potent antiviral activity of human Trim 37, and implicate an antiviral mechanism whereby Trim 37 interferes with viral DNA synthesis.

Original languageEnglish (US)
Pages (from-to)960-967
Number of pages8
JournalJournal of General Virology
Volume95
Issue numberPART 4
DOIs
StatePublished - 2014

Fingerprint Dive into the research topics of 'Anti-HIV-1 activity of trim 37'. Together they form a unique fingerprint.

Cite this