Anthropometric measures, body mass index, and pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium (PanScan)

Alan A. Arslan, Kathy J. Helzlsouer, Charles Kooperberg, Xiao Ou Shu, Emily Steplowski, H. Bas Bueno-De-Mesquita, Charles S. Fuchs, Myron D. Gross, Eric J. Jacobs, Andrea Z. LaCroix, Gloria M. Petersen, Rachael Z. Stolzenberg-Solomon, Wei Zheng, Demetrius Albanes, Laufey Amundadottir, William R. Bamlet, Aurelio Barricarte, Sheila A. Bingham, Heiner Boeing, Marie Christine Boutron-RuaultJulie E. Buring, Stephen J. Chanock, Sandra Clipp, J. Michael Gaziano, Edward L. Giovannucci, Susan E. Hankinson, Patricia Hartge, Robert N. Hoover, David J. Hunter, Amy Hutchinson, Kevin B. Jacobs, Peter Kraft, Shannon M. Lynch, Jonas Manjer, JoAnn E. Manson, Anne McTiernan, Robert R. McWilliams, Julie B. Mendelsohn, Dominique S. Michaud, Domenico Palli, Thomas E. Rohan, Nadia Slimani, Gilles Thomas, Anne Tjønneland, Geoffrey S. Tobias, Dimitrios Trichopoulos, Jarmo Virtamo, Brian M. Wolpin, Kai Yu, Anne Zeleniuch-Jacquotte, Alpa V. Patel

Research output: Contribution to journalArticlepeer-review

306 Scopus citations


Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohortspecific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese,≥35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjustedORfor the highest vs lowest BMI quartile, 1.33; 95% CI, 1.12-1.58; Ptrend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% CI, 1.04-1.69; Ptrend<.03), and in women it was 1.34 (95% CI, 1.05-1.70; Ptrend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% CI, 1.31-2.69; Ptrend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.

Original languageEnglish (US)
Pages (from-to)791-802
Number of pages12
JournalArchives of Internal Medicine
Issue number9
StatePublished - May 10 2010


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